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TNFSF9 Matched Antibody Pair (1248) (APMAB-1248LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-TNFSF9 monoclonal, IgG1 antibody, 100 ug
Detection Antibody
Anti-TNFSF9 Biotinylated mouse monoclonal, IgG1 antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]
Alternative Names
TNF Superfamily Member 9; Tumor Necrosis Factor (Ligand) Superfamily, Member 9; Homolog Of Mouse 4-1BB-L; Receptor 4-1BB Ligand; 4-1BB Ligand; 4-1BBL; Tumor Necrosis Factor Ligand Superfamily Member 9;
Entrez Gene ID
8744
UniProt ID
P41273
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For research use only. Not intended for any clinical use.

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