TNFSF9
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
Full Name
TNFSF9 Gene(Protein Coding) TNF Superfamily Member 9
Alternative Names
TNF Superfamily Member 9; Tumor Necrosis Factor (Ligand) Superfamily, Member 9; Homolog Of Mouse 4-1BB-L; Receptor 4-1BB Ligand; 4-1BB Ligand; 4-1BBL; Tumor Necrosis Factor Ligand Superfamily Member 9;
Function
Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.
Biological Process
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process immune response Source:InterPro
Biological Process positive regulation of activated T cell proliferation Source:GO_Central1 Publication
Biological Process positive regulation of cytotoxic T cell differentiation Source:GO_Central1 Publication
Biological Process regulation of apoptotic process Source:GO_Central1 Publication
Biological Process regulation of T cell proliferation Source:GO_Central1 Publication
Biological Process immune response Source:InterPro
Biological Process positive regulation of activated T cell proliferation Source:GO_Central1 Publication
Biological Process positive regulation of cytotoxic T cell differentiation Source:GO_Central1 Publication
Biological Process regulation of apoptotic process Source:GO_Central1 Publication
Biological Process regulation of T cell proliferation Source:GO_Central1 Publication
Cellular Location
Membrane
Topology
Cytoplasmic: 1-28
Helical: 29-49
Extracellular: 50-254
Helical: 29-49
Extracellular: 50-254
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Anti-TNFSF9 antibodies
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CompareTarget: TNFSF9
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: AG185
Application*: F, In Vivo
Target: TNFSF9
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: AP-MAB0875
Application*: FC, IH, IP, C, N, MC
Target: TNFSF9
Host: Rabbit
Specificity: Mouse
Clone: 14L1
Application*: FC, WB
Target: TNFSF9
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 14
Application*: FC
Target: TNFSF9
Host: Rabbit
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 8H117
Application*: E, FC, WB
Target: TNFSF9
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 203942
Application*: FC
Target: TNFSF9
Host: Rabbit
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 10B723
Application*: FC, IP
Target: TNFSF9
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C0614
Application*: E, F, WB
Target: TNFSF9
Sensitivity: 0.0052 ng/mL
Detection Range: 0.01-2 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: Tnfsf9
Sensitivity: 0.0072 ng/mL
Detection Range: 0.015-3 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: TNFSF9
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 106-308
Tag: His Tag
Target: TNFSF9
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 106-308
Tag: hFc Tag
Target: TNFSF9
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 104-309
Tag: His Tag
Target: TNFSF9
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 104-309
Tag: hFc Tag
Target: TNFSF9
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 71-254
Tag: His Tag
Target: TNFSF9
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 71-254
Tag: hFc Tag
Target: TNFSF9
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 71-254
Tag: AVI & Fc Tag
Target: TNFSF9
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 68-251
Tag: hFc Tag
Target: TNFSF9
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 68-251
Tag: hFc Tag
Target: TNFSF9
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT4367
Application*: IH, IC, F
Target: TNFSF9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4048
Application*: F
Target: TNFSF9
Specificity: Human
Target: TNFSF9
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: A1436
Application*: FC
Target: TNFSF9
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D6V6K
Application*: WB
Target: TNFSF9
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3D6
Application*: E, E
Target: TNFSF9
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D7
Application*: WB, E
Target: TNFSF9
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: CBLC271-LY
Application*: WB, IP, IF, E
Target: TNFSF9
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 9H6
Application*: E, FC, WB
Target: TNFSF9
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 9H4
Application*: FC
Target: TNFSF9
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 9H2
Application*: FC
Target: TNFSF9
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 282220
Application*: FC
Target: TNFSF9
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBWJC-4553
Application*: IP, F
Target: TNFSF9
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBWJC-4552
Application*: F, E, WB
Target: TNFSF9
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXC-2947
Application*: F
Target: TNFSF9
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0773
Application*: F
Target: TNFSF9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2013
Application*: F, WB
Target: TNFSF9
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C2012
Application*: F, WB
Target: TNFSF9
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-C0411
Application*: P
Target: Tnfsf9
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: TKS-1
Application*: B, F
Target: Tnfsf9
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJT-4019
Application*: WB, F
Target: TNFSF9
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-4018
Application*: E, F, FN, WB
Target: TNFSF9
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-4017
Application*: F
Target: TNFSF9
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 41B436
Application*: E, F, IC, WB
Target: TNFSF9
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-4016
Application*: E, WB
Target: TNFSF9
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-4015
Application*: WB, IH, IC, IP
Target: TNFSF9
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7H151
Application*: E, C, WB
Target: TNFSF9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D296
Application*: C, WB
Target: TNFSF9
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5G11
Application*: P
Target: TNFSF9
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5F4
Application*: F
Target: TNFSF9
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 41B446
Application*: C, WB
Target: TNFSF9
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 014
Application*: E, F, IC/IF, IF
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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