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TNFSF9

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]

Full Name

TNFSF9 Gene(Protein Coding) TNF Superfamily Member 9

Function

Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.

Biological Process

Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process immune response Source:InterPro
Biological Process positive regulation of activated T cell proliferation Source:GO_Central1 Publication
Biological Process positive regulation of cytotoxic T cell differentiation Source:GO_Central1 Publication
Biological Process regulation of apoptotic process Source:GO_Central1 Publication
Biological Process regulation of T cell proliferation Source:GO_Central1 Publication

Cellular Location

Membrane

Topology

Cytoplasmic: 1-28
Helical: 29-49
Extracellular: 50-254

Anti-TNFSF9 antibodies

Rat Anti-Tnfsf9 Recombinant Antibody (TKS-1) (CBMAB-T3434-YJ)

SDS

Target: Tnfsf9

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: TKS-1

Application*: B, F

Mouse Anti-TNFSF9 Recombinant Antibody (CBYY-C2012) (CBMAB-C3450-YY)

SDS

Target: TNFSF9

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYY-C2012

Application*: F, WB

Mouse Anti-TNFSF9 Recombinant Antibody (CBYY-C2013) (CBMAB-C3451-YY)

SDS

Target: TNFSF9

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-C2013

Application*: F, WB

Rat Anti-Tnfsf9 Recombinant Antibody (CBYJT-4019) (CBMAB-T3433-YJ)

SDS

Target: Tnfsf9

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: CBYJT-4019

Application*: WB, F

Mouse Anti-TNFSF9 Recombinant Antibody (CBXC-2947) (CBMAB-C4993-CQ)

SDS

Target: TNFSF9

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXC-2947

Application*: F

Mouse Anti-TNFSF9 Recombinant Antibody (CBYJT-4018) (CBMAB-T3432-YJ)

SDS

Target: TNFSF9

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJT-4018

Application*: E, F, FN, WB

Mouse Anti-TNFSF9 Recombinant Antibody (CBYJT-4017) (CBMAB-T3431-YJ)

SDS

Target: TNFSF9

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJT-4017

Application*: F

Rabbit Anti-TNFSF9 Recombinant Antibody (10B723) (CBMAB-C1014-CN)

SDS

Target: TNFSF9

Host: Rabbit

Antibody Isotype: IgG1

Specificity: Mouse

Clone: 10B723

Application*: FC, IP

Rat Anti-TNFSF9 Recombinant Antibody (203942) (CBMAB-C1015-CN)

SDS

Target: TNFSF9

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: 203942

Application*: FC

Mouse Anti-TNFSF9 Recombinant Antibody (282220) (CBMAB-C1016-CN)

SDS

Target: TNFSF9

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 282220

Application*: FC

Rabbit Anti-TNFSF9 Recombinant Antibody (8H117) (CBMAB-C1018-CN)

SDS

Target: TNFSF9

Host: Rabbit

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: 8H117

Application*: E, FC, WB

Rat Anti-TNFSF9 Recombinant Antibody (A1436) (CBMAB-AP11419LY)

SDS

Target: TNFSF9

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: A1436

Application*: FC

Rabbit Anti-TNFSF9 Recombinant Antibody (D6V6K) (CBMAB-CP2801-LY)

SDS

Target: TNFSF9

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: D6V6K

Application*: WB

Rabbit Anti-TNFSF9 Recombinant Antibody (014) (CBMAB-C0047-LY)

SDS

Target: TNFSF9

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: 014

Application*: E, F, IC/IF, IF

Mouse Anti-TNFSF9 Recombinant Antibody (41B446) (CBMAB-C6459-LY)

SDS

Target: TNFSF9

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 41B446

Application*: C, WB

Mouse Anti-TNFSF9 Recombinant Antibody (5F4) (CBMAB-C7616-LY)

SDS

Target: TNFSF9

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 5F4

Application*: F

Mouse Anti-TNFSF9 Recombinant Antibody (5G11) (CBMAB-C7656-LY)

SDS

Target: TNFSF9

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 5G11

Application*: P

Mouse Anti-TNFSF9 Recombinant Antibody (6D296) (CBMAB-C8195-LY)

SDS

Target: TNFSF9

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 6D296

Application*: C, WB

Mouse Anti-TNFSF9 Recombinant Antibody (7H151) (CBMAB-C8778-LY)

SDS

Target: TNFSF9

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 7H151

Application*: E, C, WB

Mouse Anti-TNFSF9 Recombinant Antibody (CBYY-C0411) (CBMAB-C1337-YY)

SDS

Target: TNFSF9

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYY-C0411

Application*: P

Mouse Anti-TNFSF9 Recombinant Antibody (CBYY-C0614) (CBMAB-C1902-YY)

SDS

Target: TNFSF9

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYY-C0614

Application*: E, F, WB

Human Anti-TNFSF9 Recombinant Antibody (CBXC-0773) (CBMAB-C1887-CQ)

SDS

Target: TNFSF9

Host: Human

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0773

Application*: F

Mouse Anti-TNFSF9 Recombinant Antibody (CBWJC-4552) (CBMAB-C5949WJ)

SDS

Target: TNFSF9

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBWJC-4552

Application*: F, E, WB

Rat Anti-TNFSF9 Recombinant Antibody (CBWJC-4553) (CBMAB-C5950WJ)

SDS

Target: TNFSF9

Host: Rat

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBWJC-4553

Application*: IP, F

Rabbit Anti-TNFSF9 Recombinant Antibody (14) (CBMAB-C4378-CN)

SDS

Target: TNFSF9

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: 14

Application*: FC

Rabbit Anti-TNFSF9 Recombinant Antibody (14L1) (CBMAB-C4379-CN)

SDS

Target: TNFSF9

Host: Rabbit

Specificity: Mouse

Clone: 14L1

Application*: FC, WB

Mouse Anti-TNFSF9 Recombinant Antibody (9H2) (CBMAB-C4383-CN)

SDS

Target: TNFSF9

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 9H2

Application*: FC

Mouse Anti-TNFSF9 Recombinant Antibody (9H4) (CBMAB-C4384-CN)

SDS

Target: TNFSF9

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 9H4

Application*: FC

Mouse Anti-TNFSF9 Recombinant Antibody (9H6) (CBMAB-C4385-CN)

SDS

Target: TNFSF9

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 9H6

Application*: E, FC, WB

Rat Anti-TNFSF9 Recombinant Antibody (AP-MAB0875) (CBMAB-C4386-CN)

SDS

Target: TNFSF9

Host: Rat

Antibody Isotype: IgG2

Specificity: Mouse

Clone: AP-MAB0875

Application*: FC, IH, IP, C, N, MC

Mouse Anti-TNFSF9 Recombinant Antibody (CBLC271-LY) (CBMAB-C12605-LY)

SDS

Target: TNFSF9

Host: Mouse

Antibody Isotype: IgG

Specificity: Mouse, Rat

Clone: CBLC271-LY

Application*: WB, IP, IF, E

Mouse Anti-TNFSF9 Recombinant Antibody (41B436) (CBMAB-T3430-YJ)

SDS

Target: TNFSF9

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 41B436

Application*: E, F, IC, WB

Mouse Anti-TNFSF9 Recombinant Antibody (CBYJT-4016) (CBMAB-T3429-YJ)

SDS

Target: TNFSF9

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYJT-4016

Application*: E, WB

Rabbit Anti-TNFSF9 Recombinant Antibody (CBYJT-4015) (CBMAB-T3428-YJ)

SDS

Target: TNFSF9

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-4015

Application*: WB, IH, IC, IP

Mouse Anti-TNFSF9 Recombinant Antibody (3D6) (CBMAB-A9391-LY)

SDS

Target: TNFSF9

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 3D6

Application*: E, E

Mouse Anti-TNFSF9 Recombinant Antibody (1D7) (CBMAB-A9390-LY)

SDS

Target: TNFSF9

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1D7

Application*: WB, E

TNFSF9 Matched Antibody Pair (1248) (APMAB-1248LY)

SDS

Target: TNFSF9

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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