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Mouse Anti-TNFSF9 Recombinant Antibody (41B436) (CBMAB-T3430-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TNFSF9 (TNF Superfamily Member 9). The antibody can be used for immunoassay techniques, such as ELISA, FC, ICC, WB.
See all TNFSF9 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
41B436
Antibody Isotype
IgG1, κ
Application
ELISA, FC, ICC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TNFSF9 Gene(Protein Coding) TNF Superfamily Member 9
Introduction
TNFSF9 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. TNFSF9 and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. TNFSF9 has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
Entrez Gene ID
8744
UniProt ID
P41273
Alternative Names
TNF Superfamily Member 9; Tumor Necrosis Factor (Ligand) Superfamily, Member 9; Homolog Of Mouse 4-1BB-L; Receptor 4-1BB Ligand; 4-1BB Ligand; 4-1BBL; Tumor Necrosis Factor Ligand Superfamily Member 9
Function
Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.
Biological Process
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process immune response Source:InterPro
Biological Process positive regulation of activated T cell proliferation Source:GO_Central1 Publication
Biological Process positive regulation of cytotoxic T cell differentiation Source:GO_Central1 Publication
Biological Process regulation of apoptotic process Source:GO_Central1 Publication
Biological Process regulation of T cell proliferation Source:GO_Central1 Publication
Cellular Location
Membrane
Topology
Cytoplasmic: 1-28
Helical: 29-49
Extracellular: 50-254
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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