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Mouse Anti-TNIK Recombinant Antibody (CBYJT-4022) (CBMAB-T3437-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TNIK (TRAF2 And NCK Interacting Kinase). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all TNIK antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4022
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
TNIK (AAH55427, 1aa-110aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-110

Target

Full Name
TRAF2 and NCK interacting kinase
Introduction
Wnt signaling plays important roles in carcinogenesis and embryonic development. TNIK is a serine/threonine kinase that plays a role as an activator of the Wnt signaling pathway. Mutations in this gene are associated with an autosomal recessive form of cognitive disability.
Entrez Gene ID
23043
UniProt ID
Q9UKE5
Alternative Names
TRAF2 And NCK Interacting Kinase; EC 2.7.11.1; TRAF2 And NCK-Interacting Protein Kinase; EC 2.7.11; KIAA0551; MRT54
Function
Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.
Biological Process
Biological Process actin cytoskeleton reorganization Source:UniProtKB1 Publication
Biological Process cytoskeleton organization Source:UniProtKB1 Publication
Biological Process intracellular signal transduction Source:UniProtKB1 Publication
Biological Process MAPK cascade Source:GO_Central1 Publication
Biological Process microvillus assembly Source:UniProtKB1 Publication
Biological Process neuron projection morphogenesis Source:GO_Central1 Publication
Biological Process positive regulation of JNK cascade Source:UniProtKB1 Publication
Biological Process positive regulation of protein phosphorylation Source:UniProtKB1 Publication
Biological Process protein autophosphorylation Source:UniProtKB2 Publications
Biological Process protein localization to plasma membrane Source:UniProtKB1 Publication
Biological Process protein phosphorylation Source:UniProtKB3 Publications
Biological Process regulation of dendrite morphogenesis Source:UniProtKB1 Publication
Biological Process regulation of MAPK cascade Source:GO_Central1 Publication
Biological Process response to organonitrogen compound Source:Ensembl
Biological Process Wnt signaling pathway Source:UniProtKB-KW
Cellular Location
Nucleus
Cytoplasm
Recycling endosome
Cytoplasm, cytoskeleton
Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
Involvement in disease
Intellectual developmental disorder, autosomal recessive 54 (MRT54):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT54 patients manifest intellectual disability, delayed speech and hyperactivity.
PTM
Autophosphorylated. Autophosphorylation is activated by RAP2A and induces association to the cytoskeletal fraction.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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