Mouse Anti-TNIK Recombinant Antibody (CBYJT-4024) (CBMAB-T3439-YJ)

Name: Mouse Anti-TNIK Recombinant Antibody (CBYJT-4024)
SKU: CBMAB-T3439-YJ
Rating: 5 (1 reviews)

See all TNIK antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYJT-4024

Application

Immunogen

Human TNIK aa. 522-644

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 522-644

More Infomation

Target

Full Name

TRAF2 and NCK interacting kinase

Introduction

Wnt signaling plays important roles in carcinogenesis and embryonic development. TNIK is a serine/threonine kinase that plays a role as an activator of the Wnt signaling pathway. Mutations in this gene are associated with an autosomal recessive form of cognitive disability.

Entrez Gene ID

Human	23043
Mouse	665113
Rat	294917

UniProt ID

Human	Q9UKE5
Mouse	P83510
Rat	D3ZZQ0

Alternative Names

TRAF2 And NCK Interacting Kinase; EC 2.7.11.1; TRAF2 And NCK-Interacting Protein Kinase; EC 2.7.11; KIAA0551; MRT54

Function

Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.

Biological Process

Biological Process actin cytoskeleton reorganization Source:UniProtKB1 Publication
Biological Process cytoskeleton organization Source:UniProtKB1 Publication
Biological Process intracellular signal transduction Source:UniProtKB1 Publication
Biological Process MAPK cascade Source:GO_Central1 Publication
Biological Process microvillus assembly Source:UniProtKB1 Publication
Biological Process neuron projection morphogenesis Source:GO_Central1 Publication
Biological Process positive regulation of JNK cascade Source:UniProtKB1 Publication
Biological Process positive regulation of protein phosphorylation Source:UniProtKB1 Publication
Biological Process protein autophosphorylation Source:UniProtKB2 Publications
Biological Process protein localization to plasma membrane Source:UniProtKB1 Publication
Biological Process protein phosphorylation Source:UniProtKB3 Publications
Biological Process regulation of dendrite morphogenesis Source:UniProtKB1 Publication
Biological Process regulation of MAPK cascade Source:GO_Central1 Publication
Biological Process response to organonitrogen compound Source:Ensembl
Biological Process Wnt signaling pathway Source:UniProtKB-KW

Cellular Location

Nucleus
Cytoplasm
Recycling endosome
Cytoplasm, cytoskeleton
Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.

Involvement in disease

Intellectual developmental disorder, autosomal recessive 54 (MRT54):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT54 patients manifest intellectual disability, delayed speech and hyperactivity.

PTM

Autophosphorylated. Autophosphorylation is activated by RAP2A and induces association to the cytoskeletal fraction.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-TNIK Recombinant Antibody (CBYJT-4024)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-TNIK Recombinant Antibody (CBYJT-4021) (CAT#: CBMAB-T3436-YJ)

Mouse Anti-TNIK Recombinant Antibody (CBYJT-4020) (CAT#: CBMAB-T3435-YJ)

Mouse Anti-TNIK Recombinant Antibody (CBYJT-4022) (CAT#: CBMAB-T3437-YJ)

Mouse Anti-TNIK Recombinant Antibody (CBYJT-4023) (CAT#: CBMAB-T3438-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry