TNIK

Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM

Full Name

TRAF2 and NCK interacting kinase

Function

Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.

Biological Process

Biological Process actin cytoskeleton reorganization Source:UniProtKB1 Publication
Biological Process cytoskeleton organization Source:UniProtKB1 Publication
Biological Process intracellular signal transduction Source:UniProtKB1 Publication
Biological Process MAPK cascade Source:GO_Central1 Publication
Biological Process microvillus assembly Source:UniProtKB1 Publication
Biological Process neuron projection morphogenesis Source:GO_Central1 Publication
Biological Process positive regulation of JNK cascade Source:UniProtKB1 Publication
Biological Process positive regulation of protein phosphorylation Source:UniProtKB1 Publication
Biological Process protein autophosphorylation Source:UniProtKB2 Publications
Biological Process protein localization to plasma membrane Source:UniProtKB1 Publication
Biological Process protein phosphorylation Source:UniProtKB3 Publications
Biological Process regulation of dendrite morphogenesis Source:UniProtKB1 Publication
Biological Process regulation of MAPK cascade Source:GO_Central1 Publication
Biological Process response to organonitrogen compound Source:Ensembl
Biological Process Wnt signaling pathway Source:UniProtKB-KW

Cellular Location

Nucleus
Cytoplasm
Recycling endosome
Cytoplasm, cytoskeleton
Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.

Involvement in disease

Intellectual developmental disorder, autosomal recessive 54 (MRT54):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT54 patients manifest intellectual disability, delayed speech and hyperactivity.

PTM

Autophosphorylated. Autophosphorylation is activated by RAP2A and induces association to the cytoskeletal fraction.