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Mouse Anti-TRIM56 Recombinant Antibody (4C5) (CBMAB-A9531-LY)

The product is antibody recognizes TRIM56. The antibody 4C5 immunoassay techniques such as: WB, ELISA.
See all TRIM56 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4C5
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
TRIM56 (NP_112223, 656 a.a. ~ 755 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
tripartite motif-containing 56
Entrez Gene ID
UniProt ID
Alternative Names
DKFZp667O116; FLJ35608; RNF109
Function
E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity by mediating ubiquitination of CGAS and STING1 (PubMed:21289118, PubMed:29426904).
In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity).
Also mediate monoubiquitination of CGAS, thereby promoting CGAS oligomerization and subsequent activation (PubMed:29426904).
Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES (PubMed:22948160).
Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160).
Biological Process
Biological Process defense response to virus Source:UniProtKB1 Publication
Biological Process innate immune response Source:GO_Central1 Publication
Biological Process positive regulation of DNA-templated transcription Source:GO_Central1 Publication
Biological Process positive regulation of interferon-beta production Source:UniProtKB
Biological Process positive regulation of type I interferon-mediated signaling pathway Source:UniProtKB1 Publication
Biological Process protein K63-linked ubiquitination Source:UniProtKB
Biological Process protein monoubiquitination Source:UniProtKB1 Publication
Biological Process regulation of type I interferon production Source:Reactome
Biological Process response to type I interferon Source:UniProtKB
Cellular Location
Cytoplasm
PTM
Autoubiquitinated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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