Mouse Anti-TRIM56 Recombinant Antibody (CBYJT-4821) (CBMAB-T4363-YJ)

Name: Mouse Anti-TRIM56 Recombinant Antibody (CBYJT-4821)
SKU: CBMAB-T4363-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-4821

Application

ELISA, IF, WB

Immunogen

Partial recombinant corresponding to aa656-756 from human TRIM56 (NP_112223) with GST tag. MW of the GST tag alone is 26kD

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 656-756

More Infomation

Target

Full Name

tripartite motif-containing 56

Introduction

TRIM56 (Tripartite Motif Containing 56) is a Protein Coding gene. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and Innate Immune System. Gene Ontology (GO) annotations related to TRIM56 include ubiquitin-protein transferase activity. An important paralog of TRIM56 is TRIM71.

Entrez Gene ID

81844

UniProt ID

Q9BRZ2

Alternative Names

Tripartite Motif Containing 56; RING-Type E3 Ubiquitin Transferase TRIM56; Tripartite Motif-Containing Protein 56; RING Finger Protein 109; RNF109; E3 Ubiquitin-Protein Ligase TRIM56; Tripartite Motif-Containing 56; EC 2.3.2.27

Function

E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity by mediating ubiquitination of CGAS and STING1 (PubMed:21289118, PubMed:29426904).
In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity).
Also mediate monoubiquitination of CGAS, thereby promoting CGAS oligomerization and subsequent activation (PubMed:29426904).
Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES (PubMed:22948160).
Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160).

Biological Process

Biological Process defense response to virus Source:UniProtKB1 Publication
Biological Process innate immune response Source:GO_Central1 Publication
Biological Process positive regulation of DNA-templated transcription Source:GO_Central1 Publication
Biological Process positive regulation of interferon-beta production Source:UniProtKB
Biological Process positive regulation of type I interferon-mediated signaling pathway Source:UniProtKB1 Publication
Biological Process protein K63-linked ubiquitination Source:UniProtKB
Biological Process protein monoubiquitination Source:UniProtKB1 Publication
Biological Process regulation of type I interferon production Source:Reactome
Biological Process response to type I interferon Source:UniProtKB

Cellular Location

Cytoplasm

PTM

Autoubiquitinated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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