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Mouse Anti-TRIM56 Recombinant Antibody (CBYJT-4821) (CBMAB-T4363-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRIM56 (Tripartite Motif Containing 56). The antibody can be used for immunoassay techniques, such as ELISA, IF, WB.
See all TRIM56 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4821
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa656-756 from human TRIM56 (NP_112223) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 656-756

Target

Full Name
tripartite motif-containing 56
Introduction
TRIM56 (Tripartite Motif Containing 56) is a Protein Coding gene. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and Innate Immune System. Gene Ontology (GO) annotations related to TRIM56 include ubiquitin-protein transferase activity. An important paralog of TRIM56 is TRIM71.
Entrez Gene ID
81844
UniProt ID
Q9BRZ2
Alternative Names
Tripartite Motif Containing 56; RING-Type E3 Ubiquitin Transferase TRIM56; Tripartite Motif-Containing Protein 56; RING Finger Protein 109; RNF109; E3 Ubiquitin-Protein Ligase TRIM56; Tripartite Motif-Containing 56; EC 2.3.2.27
Function
E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity by mediating ubiquitination of CGAS and STING1 (PubMed:21289118, PubMed:29426904).
In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity).
Also mediate monoubiquitination of CGAS, thereby promoting CGAS oligomerization and subsequent activation (PubMed:29426904).
Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES (PubMed:22948160).
Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160).
Biological Process
Biological Process defense response to virus Source:UniProtKB1 Publication
Biological Process innate immune response Source:GO_Central1 Publication
Biological Process positive regulation of DNA-templated transcription Source:GO_Central1 Publication
Biological Process positive regulation of interferon-beta production Source:UniProtKB
Biological Process positive regulation of type I interferon-mediated signaling pathway Source:UniProtKB1 Publication
Biological Process protein K63-linked ubiquitination Source:UniProtKB
Biological Process protein monoubiquitination Source:UniProtKB1 Publication
Biological Process regulation of type I interferon production Source:Reactome
Biological Process response to type I interferon Source:UniProtKB
Cellular Location
Cytoplasm
PTM
Autoubiquitinated.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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