TRIM56

TRIM56 (Tripartite Motif Containing 56) is a Protein Coding gene. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and Innate Immune System. Gene Ontology (GO) annotations related to TRIM56 include ubiquitin-protein transferase activity. An important paralog of TRIM56 is TRIM71.

Full Name

tripartite motif-containing 56

Function

E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity by mediating ubiquitination of CGAS and STING1 (PubMed:21289118, PubMed:29426904).
In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity).
Also mediate monoubiquitination of CGAS, thereby promoting CGAS oligomerization and subsequent activation (PubMed:29426904).
Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES (PubMed:22948160).
Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160).

Biological Process

Biological Process defense response to virus Source:UniProtKB1 Publication
Biological Process innate immune response Source:GO_Central1 Publication
Biological Process positive regulation of DNA-templated transcription Source:GO_Central1 Publication
Biological Process positive regulation of interferon-beta production Source:UniProtKB
Biological Process positive regulation of type I interferon-mediated signaling pathway Source:UniProtKB1 Publication
Biological Process protein K63-linked ubiquitination Source:UniProtKB
Biological Process protein monoubiquitination Source:UniProtKB1 Publication
Biological Process regulation of type I interferon production Source:Reactome
Biological Process response to type I interferon Source:UniProtKB

Cellular Location

Cytoplasm

PTM

Autoubiquitinated.