Sign in or Register   Sign in or Register
  |  

Mouse Anti-TRIM58 Recombinant Antibody (2H3) (CBMAB-A9532-LY)

The product is antibody recognizes TRIM58. The antibody 2H3 immunoassay techniques such as: ELISA.
See all TRIM58 antibodies
Published Data
Fig.1 Trim58 Is Expressed during Late-Stage Erythropoiesis and Regulates Erythroid Maturation.
...View More
Fig.2 Trim58 Ubiquitinates Dynein and Promotes Its Proteasomal Degradation.
...View More
Fig.3 Trim58 Ubiquitinates Dynein and Promotes Its Proteasomal Degradation.
...View More
Fig.4 Trim58 Expression Correlates with Loss of Dynein and Enucleation during Erythroid Maturation.
...View More
Fig.5 Trim58 Regulates Nuclear Polarization and Extrusion during Erythropoiesis.
...View More

Summary

Host Animal
Mouse
Specificity
Human
Clone
2H3
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
TRIM58 (NP_056246, 346 a.a. ~ 445 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
tripartite motif-containing 58
Entrez Gene ID
25893
UniProt ID
Q8NG06
Alternative Names
BIA2; DKFZp434C091
Function
E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization.
Biological Process
Biological Process innate immune response Source:GO_Central1 Publication
Biological Process positive regulation of erythrocyte enucleation Source:Ensembl
Biological Process protein autoubiquitination Source:Ensembl
Biological Process protein polyubiquitination Source:Ensembl
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process regulation of gene expression Source:GO_Central1 Publication
Biological Process regulation of nuclear migration along microtubule Source:Ensembl
Biological Process ubiquitin-dependent protein catabolic process Source:Ensembl
Cellular Location
Cytoplasm
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-TRIM58 Recombinant Antibody (2H3)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare