TRIM58

TRIM58 (Tripartite Motif Containing 58) is a Protein Coding gene. Gene Ontology (GO) annotations related to TRIM58 include ligase activity. An important paralog of TRIM58 is TRIM11.

Full Name

tripartite motif-containing 58

Function

E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization.

Biological Process

Biological Process innate immune response Source:GO_Central1 Publication
Biological Process positive regulation of erythrocyte enucleation Source:Ensembl
Biological Process protein autoubiquitination Source:Ensembl
Biological Process protein polyubiquitination Source:Ensembl
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process regulation of gene expression Source:GO_Central1 Publication
Biological Process regulation of nuclear migration along microtubule Source:Ensembl
Biological Process ubiquitin-dependent protein catabolic process Source:Ensembl

Cellular Location

Cytoplasm