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Mouse Anti-TRIM58 Recombinant Antibody (CBYJT-4824) (CBMAB-T4366-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4824
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
TRIM58 (NP_056246, 346 a.a. ~ 445 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: HYWEVLVGEG AEWGLGVCQD TLPRKGETTP SPENGVWALW LLKGNEYMVL ASPSVPLLQL ESPRCIGIFL DYEAGEISFY NVTDGSYIYT FNQLFSGLLR
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 346-445

Target

Full Name
tripartite motif-containing 58
Introduction
TRIM58 (Tripartite Motif Containing 58) is a Protein Coding gene. Gene Ontology (GO) annotations related to TRIM58 include ligase activity. An important paralog of TRIM58 is TRIM11.
Entrez Gene ID
25893
UniProt ID
Q8NG06
Alternative Names
Tripartite Motif Containing 58; RING-Type E3 Ubiquitin Transferase TRIM58; Tripartite Motif-Containing Protein 58; E3 Ubiquitin-Protein Ligase TRIM58; Tripartite Motif-Containing 58; Protein BIA2; EC 2.3.2.27; BIA2
Function
E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization.
Biological Process
Biological Process innate immune response Source:GO_Central1 Publication
Biological Process positive regulation of erythrocyte enucleation Source:Ensembl
Biological Process protein autoubiquitination Source:Ensembl
Biological Process protein polyubiquitination Source:Ensembl
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process regulation of gene expression Source:GO_Central1 Publication
Biological Process regulation of nuclear migration along microtubule Source:Ensembl
Biological Process ubiquitin-dependent protein catabolic process Source:Ensembl
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

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