Mouse Anti-TRIM58 Recombinant Antibody (CBYJT-4824) (CBMAB-T4366-YJ)

Name: Mouse Anti-TRIM58 Recombinant Antibody (CBYJT-4824)
SKU: CBMAB-T4366-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-4824

Application

ELISA

Immunogen

TRIM58 (NP_056246, 346 a.a. ~ 445 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: HYWEVLVGEG AEWGLGVCQD TLPRKGETTP SPENGVWALW LLKGNEYMVL ASPSVPLLQL ESPRCIGIFL DYEAGEISFY NVTDGSYIYT FNQLFSGLLR

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 346-445

More Infomation

Target

Full Name

tripartite motif-containing 58

Introduction

TRIM58 (Tripartite Motif Containing 58) is a Protein Coding gene. Gene Ontology (GO) annotations related to TRIM58 include ligase activity. An important paralog of TRIM58 is TRIM11.

Entrez Gene ID

25893

UniProt ID

Q8NG06

Alternative Names

Tripartite Motif Containing 58; RING-Type E3 Ubiquitin Transferase TRIM58; Tripartite Motif-Containing Protein 58; E3 Ubiquitin-Protein Ligase TRIM58; Tripartite Motif-Containing 58; Protein BIA2; EC 2.3.2.27; BIA2

Function

E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization.

Biological Process

Biological Process innate immune response Source:GO_Central1 Publication
Biological Process positive regulation of erythrocyte enucleation Source:Ensembl
Biological Process protein autoubiquitination Source:Ensembl
Biological Process protein polyubiquitination Source:Ensembl
Biological Process protein ubiquitination Source:GO_Central1 Publication
Biological Process regulation of gene expression Source:GO_Central1 Publication
Biological Process regulation of nuclear migration along microtubule Source:Ensembl
Biological Process ubiquitin-dependent protein catabolic process Source:Ensembl

Cellular Location

Cytoplasm

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-TRIM58 Recombinant Antibody (2H3) (CAT#: CBMAB-A9532-LY)

Isotype control

For research use only. Not intended for any clinical use.

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