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Mouse Anti-TRIM72 Recombinant Antibody (2G1) (CBMAB-A9537-LY)

The product is antibody recognizes TRIM72. The antibody 2G1 immunoassay techniques such as: WB, ELISA.
See all TRIM72 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2G1
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
TRIM72 (NP_001008275.1, 378 a.a. ~ 477 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Tripartite Motif Containing 72
Entrez Gene ID
493829
UniProt ID
Q6ZMU5
Function
Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca2+-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).
Biological Process
Biological Process exocytosis Source:UniProtKB-KW
Biological Process muscle organ development Source:UniProtKB
Biological Process muscle system process Source:UniProtKB
Biological Process negative regulation of insulin receptor signaling pathway Source:Ensembl
Biological Process negative regulation of insulin-like growth factor receptor signaling pathway Source:Ensembl
Biological Process negative regulation of myotube differentiation Source:Ensembl
Biological Process plasma membrane repair Source:UniProtKB
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication
Biological Process protein homooligomerization Source:UniProtKB
Biological Process protein ubiquitination Source:GO_Central1 Publication
Cellular Location
Cell membrane, sarcolemma
Cytoplasmic vesicle membrane
Tethered to plasma membrane and cytoplasmic vesicles via its interaction with phosphatidylserine.
PTM
Disulfide bond formation at Cys-242 oCcurs in case of membrane damage that cause the entry of the oxidized milieu of the extracellular space, resulting in homooligomerization.
S-nitrosylation at Cys-144 stabilizes TRIM72 and protects against oxidation-induced protein degradation and cell death.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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