Mouse Anti-TRIM72 Recombinant Antibody (CBYJL-2380) (CBMAB-L2690-YJ)

Name: Mouse Anti-TRIM72 Recombinant Antibody (CBYJL-2380)
SKU: CBMAB-L2690-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJL-2380

Application

ELISA, IP

Immunogen

LOC493829 (NP_001008275.1, 378aa -477aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 378-477

More Infomation

Target

Full Name

Tripartite Motif Containing 72

Introduction

Among its related pathways are Cardiac conduction and Smooth Muscle Contraction. Gene Ontology (GO) annotations related to this gene include phosphatidylserine binding. An important paralog of this gene is TRIM50.

Entrez Gene ID

493829

UniProt ID

Q6ZMU5

Alternative Names

Tripartite Motif Containing 72; Tripartite Motif Containing 72, E3 Ubiquitin Protein Ligase; Mitsugumin-53; MG53; Tripartite Motif-Containing Protein 72; Tripartite Motif-Containing 72; Mitsugumin 53

Function

Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca2+-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).

Biological Process

Biological Process exocytosis Source:UniProtKB-KW
Biological Process muscle organ development Source:UniProtKB
Biological Process muscle system process Source:UniProtKB
Biological Process negative regulation of insulin receptor signaling pathway Source:Ensembl
Biological Process negative regulation of insulin-like growth factor receptor signaling pathway Source:Ensembl
Biological Process negative regulation of myotube differentiation Source:Ensembl
Biological Process plasma membrane repair Source:UniProtKB
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication
Biological Process protein homooligomerization Source:UniProtKB
Biological Process protein ubiquitination Source:GO_Central1 Publication

Cellular Location

Cell membrane, sarcolemma
Cytoplasmic vesicle membrane
Tethered to plasma membrane and cytoplasmic vesicles via its interaction with phosphatidylserine.

PTM

Disulfide bond formation at Cys-242 ^oCcurs in case of membrane damage that cause the entry of the oxidized milieu of the extracellular space, resulting in homooligomerization.
S-nitrosylation at Cys-144 stabilizes TRIM72 and protects against oxidation-induced protein degradation and cell death.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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