Mouse Trim72 ELISA Kit (V2LY-0626-LY3149)

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Tested Data
Datasheet
SDS
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Basic Information

Sensitivity
0.0091 ng/mL
Detection Range
0.02-4.5 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Mouse
Assay Type
Sandwich
Reactivity
Mouse
Assay Time
1.5 h
Molecule Mass
52.8 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Tripartite Motif Containing 72
Function
Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca2+-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).
Biological Process
Biological Process exocytosis Source:UniProtKB-KW
Biological Process muscle organ development Source:UniProtKB
Biological Process muscle system process Source:UniProtKB
Biological Process negative regulation of insulin receptor signaling pathway Source:Ensembl
Biological Process negative regulation of insulin-like growth factor receptor signaling pathway Source:Ensembl
Biological Process negative regulation of myotube differentiation Source:Ensembl
Biological Process plasma membrane repair Source:UniProtKB
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication
Biological Process protein homooligomerization Source:UniProtKB
Biological Process protein ubiquitination Source:GO_Central1 Publication
Cellular Location
Cell membrane, sarcolemma
Cytoplasmic vesicle membrane
Tethered to plasma membrane and cytoplasmic vesicles via its interaction with phosphatidylserine.
PTM
Disulfide bond formation at Cys-242 oCcurs in case of membrane damage that cause the entry of the oxidized milieu of the extracellular space, resulting in homooligomerization.
S-nitrosylation at Cys-144 stabilizes TRIM72 and protects against oxidation-induced protein degradation and cell death.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rat Trim72 ELISA Kit (CAT#: V2LY-0626-LY2778)

Human TRIM72 ELISA Kit (CAT#: V2LY-0626-LY5369)

Related Products

Rat Trim72 ELISA Kit (CAT#: V2LY-0626-LY2778)

Mouse Anti-TRIM72 Recombinant Antibody (CBYJT-4831) (CAT#: CBMAB-T4374-YJ)

Mouse Anti-TRIM72 Recombinant Antibody (3B5) (CAT#: CBMAB-A9538-LY)

Mouse Anti-TRIM72 Recombinant Antibody (CBYJT-4832) (CAT#: CBMAB-T4375-YJ)

Mouse Anti-TRIM72 Recombinant Antibody (CBYJL-2379) (CAT#: CBMAB-L2689-YJ)

Mouse Anti-TRIM72 Recombinant Antibody (CBYJT-4830) (CAT#: CBMAB-T4373-YJ)

Mouse Anti-TRIM72 Recombinant Antibody (2B8) (CAT#: CBMAB-A9536-LY)

Mouse Anti-TRIM72 Recombinant Antibody (2G1) (CAT#: CBMAB-A9537-LY)

Mouse Anti-TRIM72 Recombinant Antibody (CBYJL-2380) (CAT#: CBMAB-L2690-YJ)

Human TRIM72 ELISA Kit (CAT#: V2LY-0626-LY5369)

Isotype control

For research use only. Not intended for any clinical use.

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