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Mouse Anti-TRMT2A Recombinant Antibody (CBYJT-4871) (CBMAB-T4417-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRMT2A (TRNA Methyltransferase 2 Homolog A). The antibody can be used for immunoassay techniques, such as WB, IF, FC.
See all TRMT2A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4871
Antibody Isotype
IgG1
Application
WB, IF, FC

Basic Information

Immunogen
Full length human recombinant protein of human TRMT2A(NP_073564) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
Introduction
TRMT2A is of unknown function. However, it is orthologous to the mouse Trmt2a gene and contains an RNA methyltransferase domain. Expression of this gene varies during the cell cycle, with aberrant expression being a possible biomarker in certain breast cancers.
Entrez Gene ID
27037
UniProt ID
Q8IZ69
Alternative Names
TRNA Methyltransferase 2 Homolog A; HpaII Tiny Fragments Locus 9c Protein; HTF9C; TRNA Methyltransferase 2 Homolog A (S. Cerevisiae); TRNA (Uracil-5-)-Methyltransferase Homolog A; TRM2 TRNA Methyltransferase 2 Homolog A; HpaII Tiny Fragments Locus 9C; EC 2.1.1.-
Function
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and some mRNAs (PubMed:31361898, PubMed:33799331, PubMed:34556860).
Mainly catalyzes the methylation of uridine at position 54 (m5U54) in cytosolic tRNAs (PubMed:31361898, PubMed:33799331).
Also able to mediate the formation of 5-methyl-uridine in some mRNAs (PubMed:34123281).
Biological Process
Biological Process mRNA processing Source:UniProtKB-KW
Cellular Location
Cytoplasm, cytosol
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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