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Mouse Anti-TRPC1 Recombinant Antibody (CBYJT-4896) (CBMAB-T4442-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRPC1 (Transient Receptor Potential Cation Channel Subfamily C Member 1). The antibody can be used for immunoassay techniques, such as ELISA.
See all TRPC1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4896
Antibody Isotype
IgG2b, κ
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Transient Receptor Potential Cation Channel Subfamily C Member 1
Introduction
TRPC1 is a membrane protein that can form a non-selective channel permeable to calcium and other cations. TRPC1 appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores.
Entrez Gene ID
7220
UniProt ID
P48995
Alternative Names
Transient Receptor Potential Cation Channel Subfamily C Member 1; Transient Receptor Protein 1; TRP-1; TRP1; Transient Receptor Potential Cation Channel, Subfamily C, Member 1; Short Transient Receptor Potential Channel 1
Function
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.
Biological Process
Biological Process calcium ion transmembrane transport Source:GO_Central1 Publication
Biological Process calcium ion transport Source:ProtInc1 Publication
Biological Process manganese ion transport Source:GO_Central1 Publication
Biological Process melanin biosynthetic process Source:CACAO1 Publication
Biological Process positive regulation of release of sequestered calcium ion into cytosol Source:BHF-UCL1 Publication
Biological Process regulation of cardiac conduction Source:Reactome
Biological Process regulation of cytosolic calcium ion concentration Source:BHF-UCL1 Publication
Biological Process response to calcium ion Source:BHF-UCL2 Publications
Cellular Location
Membrane
Topology
Cytoplasmic: 1-386
Helical: 387-407
Extracellular: 408-415
Helical: 416-436
Cytoplasmic: 437-457
Helical: 458-475
Extracellular: 476-539
Helical: 540-560
Cytoplasmic: 561-586
Helical: 587-607
Extracellular: 608-616
Helical: 617-637
PTM
Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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