Rabbit Anti-TRPC1 Recombinant Antibody (CBYJT-4897) (CBMAB-T4443-YJ)

Name: Rabbit Anti-TRPC1 Recombinant Antibody (CBYJT-4897)
SKU: CBMAB-T4443-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBYJT-4897

Application

WB, IP, FC

Immunogen

Synthetic peptide: KFHDFADRKDWDAFC (Human)

Specificity

Human, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Transient Receptor Potential Cation Channel Subfamily C Member 1

Introduction

TRPC1 is a membrane protein that can form a non-selective channel permeable to calcium and other cations. TRPC1 appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores.

Entrez Gene ID

Human	7220
Rat	89821

UniProt ID

Human	P48995
Rat	Q9QX01

Alternative Names

Transient Receptor Potential Cation Channel Subfamily C Member 1; Transient Receptor Protein 1; TRP-1; TRP1; Transient Receptor Potential Cation Channel, Subfamily C, Member 1; Short Transient Receptor Potential Channel 1

Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

Biological Process

Biological Process calcium ion transmembrane transport Source:GO_Central1 Publication
Biological Process calcium ion transport Source:ProtInc1 Publication
Biological Process manganese ion transport Source:GO_Central1 Publication
Biological Process melanin biosynthetic process Source:CACAO1 Publication
Biological Process positive regulation of release of sequestered calcium ion into cytosol Source:BHF-UCL1 Publication
Biological Process regulation of cardiac conduction Source:Reactome
Biological Process regulation of cytosolic calcium ion concentration Source:BHF-UCL1 Publication
Biological Process response to calcium ion Source:BHF-UCL2 Publications

Cellular Location

Membrane

Topology

Cytoplasmic: 1-386
Helical: 387-407
Extracellular: 408-415
Helical: 416-436
Cytoplasmic: 437-457
Helical: 458-475
Extracellular: 476-539
Helical: 540-560
Cytoplasmic: 561-586
Helical: 587-607
Extracellular: 608-616
Helical: 617-637

PTM

Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-TRPC1 Recombinant Antibody (CBYJT-4896) (CAT#: CBMAB-T4442-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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