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Rabbit Anti-TRPC1 Recombinant Antibody (CBYJT-4897) (CBMAB-T4443-YJ)


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Summary

Host Animal
Rabbit
Specificity
Human, Rat
Clone
CBYJT-4897
Antibody Isotype
IgG
Application
WB, IP, FC

Basic Information

Immunogen
Synthetic peptide: KFHDFADRKDWDAFC (Human)
Specificity
Human, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Transient Receptor Potential Cation Channel Subfamily C Member 1
Introduction
TRPC1 is a membrane protein that can form a non-selective channel permeable to calcium and other cations. TRPC1 appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores.
Entrez Gene ID
Human7220
Rat89821
UniProt ID
HumanP48995
RatQ9QX01
Alternative Names
Transient Receptor Potential Cation Channel Subfamily C Member 1; Transient Receptor Protein 1; TRP-1; TRP1; Transient Receptor Potential Cation Channel, Subfamily C, Member 1; Short Transient Receptor Potential Channel 1
Function
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.
Biological Process
Biological Process calcium ion transmembrane transport Source:GO_Central1 Publication
Biological Process calcium ion transport Source:ProtInc1 Publication
Biological Process manganese ion transport Source:GO_Central1 Publication
Biological Process melanin biosynthetic process Source:CACAO1 Publication
Biological Process positive regulation of release of sequestered calcium ion into cytosol Source:BHF-UCL1 Publication
Biological Process regulation of cardiac conduction Source:Reactome
Biological Process regulation of cytosolic calcium ion concentration Source:BHF-UCL1 Publication
Biological Process response to calcium ion Source:BHF-UCL2 Publications
Cellular Location
Membrane
Topology
Cytoplasmic: 1-386
Helical: 387-407
Extracellular: 408-415
Helical: 416-436
Cytoplasmic: 437-457
Helical: 458-475
Extracellular: 476-539
Helical: 540-560
Cytoplasmic: 561-586
Helical: 587-607
Extracellular: 608-616
Helical: 617-637
PTM
Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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