TRPC1

TRPC1 is a membrane protein that can form a non-selective channel permeable to calcium and other cations. TRPC1 appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores.

Full Name

Transient Receptor Potential Cation Channel Subfamily C Member 1

Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

Biological Process

Biological Process calcium ion transmembrane transport Source:GO_Central1 Publication
Biological Process calcium ion transport Source:ProtInc1 Publication
Biological Process manganese ion transport Source:GO_Central1 Publication
Biological Process melanin biosynthetic process Source:CACAO1 Publication
Biological Process positive regulation of release of sequestered calcium ion into cytosol Source:BHF-UCL1 Publication
Biological Process regulation of cardiac conduction Source:Reactome
Biological Process regulation of cytosolic calcium ion concentration Source:BHF-UCL1 Publication
Biological Process response to calcium ion Source:BHF-UCL2 Publications

Cellular Location

Membrane

Topology

Cytoplasmic: 1-386
Helical: 387-407
Extracellular: 408-415
Helical: 416-436
Cytoplasmic: 437-457
Helical: 458-475
Extracellular: 476-539
Helical: 540-560
Cytoplasmic: 561-586
Helical: 587-607
Extracellular: 608-616
Helical: 617-637

PTM

Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells.