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Mouse Anti-TRPC7 Recombinant Antibody (CBYJT-4911) (CBMAB-T4460-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TRPC7 (Transient Receptor Potential Cation Channel Subfamily C Member 7). The antibody can be used for immunoassay techniques, such as IF, IHC, IP, WB.
See all TRPC7 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYJT-4911
Antibody Isotype
IgG1
Application
IF, IHC, IP, WB

Basic Information

Immunogen
Synthetic peptide corresponding to aa845-862 of human TRPC7 (UniProt Accession #Q9HCX4)
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 50% Glycerol
Preservative
0.09% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 845-862

Target

Full Name
Transient Receptor Potential Cation Channel Subfamily C Member 7
Introduction
TRPC7 (TRPC7 Antisense RNA 1) is an RNA Gene, and is affiliated with the non-coding RNA class.
Entrez Gene ID
Human57113
Mouse26946
Rat282822
UniProt ID
HumanQ9HCX4
MouseQ9WVC5
RatF1LQF7
Alternative Names
Transient Receptor Potential Cation Channel Subfamily C Member 7; Transient Receptor Protein 7; TRP-7; HTRP7; TRP7; Likley Ortholog Of Mouse Transient Receptor Potential Cation Channel, Subfamily C, Member 7
Function
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity).
May also be activated by intracellular calcium store depletion.
Biological Process
Biological Process calcium ion transmembrane transport Source:GO_Central1 Publication
Biological Process manganese ion transport Source:GO_Central1 Publication
Biological Process regulation of cytosolic calcium ion concentration Source:GO_Central1 Publication
Biological Process single fertilization Source:GO_Central1 Publication
Cellular Location
Cell membrane
Nucleus envelope
Topology
Cytoplasmic: 1-351
Helical: 352-372
Extracellular: 373-383
Helical: 384-404
Cytoplasmic: 405-465
Helical: 466-486
Extracellular: 487-537
Helical: 538-558
Cytoplasmic: 559-581
Helical: 582-602
Extracellular: 603-651
Helical: 652-672
Cytoplasmic: 673-862
PTM
Phosphorylation by PRKG1 at Thr-15 negatively regulates TRPC7 activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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