Mouse Anti-TRPC7 Recombinant Antibody (CBYJT-4912) (CBMAB-T4462-YJ)

Name: Mouse Anti-TRPC7 Recombinant Antibody (CBYJT-4912)
SKU: CBMAB-T4462-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBYJT-4912

Application

ICC, IHC-P, IP, WB

Immunogen

Synthetic peptide amino acids 845-862 of human TRPC7, accession number Q9HCX4

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4, 50% Glycerol

Preservative

0.09% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 845-862

More Infomation

Target

Full Name

Transient Receptor Potential Cation Channel Subfamily C Member 7

Introduction

TRPC7 (TRPC7 Antisense RNA 1) is an RNA Gene, and is affiliated with the non-coding RNA class.

Entrez Gene ID

Human	57113
Mouse	26946
Rat	282822

UniProt ID

Human	Q9HCX4
Mouse	Q9WVC5
Rat	F1LQF7

Alternative Names

Transient Receptor Potential Cation Channel Subfamily C Member 7; Transient Receptor Protein 7; TRP-7; HTRP7; TRP7; Likley Ortholog Of Mouse Transient Receptor Potential Cation Channel, Subfamily C, Member 7

Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) (By similarity).
May also be activated by intracellular calcium store depletion.

Biological Process

Biological Process calcium ion transmembrane transport Source:GO_Central1 Publication
Biological Process manganese ion transport Source:GO_Central1 Publication
Biological Process regulation of cytosolic calcium ion concentration Source:GO_Central1 Publication
Biological Process single fertilization Source:GO_Central1 Publication

Cellular Location

Cell membrane
Nucleus envelope

Topology

Cytoplasmic: 1-351
Helical: 352-372
Extracellular: 373-383
Helical: 384-404
Cytoplasmic: 405-465
Helical: 466-486
Extracellular: 487-537
Helical: 538-558
Cytoplasmic: 559-581
Helical: 582-602
Extracellular: 603-651
Helical: 652-672
Cytoplasmic: 673-862

PTM

Phosphorylation by PRKG1 at Thr-15 negatively regulates TRPC7 activity.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

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Mouse Anti-TRPC7 Recombinant Antibody (CBYJT-4911) (CAT#: CBMAB-T4460-YJ)

Isotype control

For research use only. Not intended for any clinical use.

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