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Mouse Anti-TSEN15 Recombinant Antibody (CBXS-2216) (CBMAB-S4978-CQ)

This product is a mouse antibody that recognizes TSEN15. The antibody CBXS-2216 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all TSEN15 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBXS-2216
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TSEN15 Gene(Protein Coding)


TRNA Splicing Endonuclease Subunit 15
Introduction
This gene encodes a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from tRNA precursors. Alternative splicing results in multiple transcript variants. There is a pseudogene of this gene on chromosome 17.
Entrez Gene ID
Human116461
Mouse66637
Rat289083
UniProt ID
HumanQ8WW01
MouseQ8R3W5
RatD3ZFW1
Alternative Names
TRNA Splicing Endonuclease Subunit 15; TSEN15 TRNA Splicing Endonuclease Subunit; TRNA-Intron Endonuclease Sen15; C1orf19; Sen15; TRNA Splicing Endonuclease 15 Homolog (S. Cerevisiae); TRNA-Splicing Endonuclease Subunit Sen15;
Function
Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini (PubMed:15109492, PubMed:27392077).
There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (PubMed:15109492).
Biological Process
Biological Process mRNA processing Source:UniProtKB-KW
Biological Process tRNA splicing, via endonucleolytic cleavage and ligation Source:InterPro
Cellular Location
Nucleus
Nucleus, nucleolus
May be transiently localized in the nucleolus.
Involvement in disease
Pontocerebellar hypoplasia 2F (PCH2F):
A neurodevelopmental disorder characterized by progressive microcephaly, cognitive and motor delay, poor or absent speech, seizures, and spasticity. PCH2F inheritance is autosomal recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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