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Mouse Anti-TSEN15 Recombinant Antibody (CBYY-C2032) (CBMAB-C3470-YY)

This product is mouse antibody that recognizes TSEN15. The antibody CBYY-C2032 can be used for immunoassay techniques such as: ELISA, IF, WB
See all TSEN15 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C2032
Antibody Isotype
IgG1, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa72-171 from human C1orf19 (NP_443197) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein A purified
Preservative
PBS, pH 7.2
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TSEN15 Gene(Protein Coding)


TRNA Splicing Endonuclease Subunit 15
Entrez Gene ID
116461
UniProt ID
Q8WW01
Alternative Names
Cell Adhesion Molecule L1 Like; Close Homolog Of L1; Cell Adhesion Molecule With Homology To L1CAM (Close Homologue Of L1); Cell Adhesion Molecule With Homology To L1CAM (Close Homolog Of L1); CALL; Neural Cell Adhesion Molecule L1-Like Protein;
Function
Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini (PubMed:15109492, PubMed:27392077).
There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (PubMed:15109492).
Biological Process
Biological Process mRNA processing Source:UniProtKB-KW
Biological Process tRNA splicing, via endonucleolytic cleavage and ligation Source:InterPro
Cellular Location
Nucleus
Nucleus, nucleolus
May be transiently localized in the nucleolus.
Involvement in disease
Pontocerebellar hypoplasia 2F (PCH2F):
A neurodevelopmental disorder characterized by progressive microcephaly, cognitive and motor delay, poor or absent speech, seizures, and spasticity. PCH2F inheritance is autosomal recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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