Mouse Anti-TSEN15 Recombinant Antibody (CBYJT-4992) (CBMAB-T4549-YJ)

Name: Mouse Anti-TSEN15 Recombinant Antibody (CBYJT-4992)
SKU: CBMAB-T4549-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-4992

Application

ELISA, IF, WB

Immunogen

Partial recombinant corresponding to aa72-171 from human C1orf19 (NP_443197) with GST tag. MW of the GST tag alone is 26kD

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 72-171

More Infomation

Target

Full Name

TSEN15 Gene(Protein Coding)

TRNA Splicing Endonuclease Subunit 15

Introduction

TSEN15 is a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from tRNA precursors.

Entrez Gene ID

116461

UniProt ID

Q8WW01

Alternative Names

TRNA Splicing Endonuclease Subunit 15; TSEN15 TRNA Splicing Endonuclease Subunit; TRNA-Intron Endonuclease Sen15; C1orf19; Sen15; TRNA Splicing Endonuclease 15 Homolog (S. Cerevisiae); TRNA-Splicing Endonuclease Subunit Sen15

Function

Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini (PubMed:15109492, PubMed:27392077).
There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (PubMed:15109492).

Biological Process

Biological Process mRNA processing Source:UniProtKB-KW
Biological Process tRNA splicing, via endonucleolytic cleavage and ligation Source:InterPro

Cellular Location

Nucleus
Nucleus, nucleolus
May be transiently localized in the nucleolus.

Involvement in disease

Pontocerebellar hypoplasia 2F (PCH2F):
A neurodevelopmental disorder characterized by progressive microcephaly, cognitive and motor delay, poor or absent speech, seizures, and spasticity. PCH2F inheritance is autosomal recessive.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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