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Mouse Anti-TSSK1B Recombinant Antibody (4F12) (CBMAB-A9590-LY)

The product is antibody recognizes TSSK1B. The antibody 4F12 immunoassay techniques such as: WB, ELISA.
See all TSSK1B antibodies
Published Data
Fig.1 Validation of antibodies against human Tssks by immunoblot analysis.
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Fig.2 Analysis of Tssks in mouse testis and in purified spermatogenic cells.
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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
4F12
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
TSSK1B (AAH22515, 267 a.a. ~ 367 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human, Mouse
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
testis-specific serine kinase 1B
Introduction
TSSK1 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM
Entrez Gene ID
83942
UniProt ID
Q9BXA7
Alternative Names
FKSG81; SPOGA4; STK22D; TSSK1
Function
Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-288' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body.
Biological Process
Biological Process intracellular signal transduction Source:GO_Central1 Publication
Biological Process peptidyl-serine phosphorylation Source:Ensembl
Biological Process protein phosphorylation Source:UniProtKB1 Publication
Biological Process spermatid development Source:UniProtKB
Cellular Location
Cytoplasm
Cytoplasmic vesicle, secretory vesicle, acrosome
Cell projection, cilium, flagellum
In spermatozoa, present in the sperm head and in the flagellum.
PTM
Autophosphorylated.
Ubiquitinated; HSP90 activity negatively regulates ubiquitination and degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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