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Mouse Anti-TTF2 Recombinant Antibody (CBYJT-5148) (CBMAB-T4726-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TTF2 (Transcription Termination Factor 2). The antibody can be used for immunoassay techniques, such as ELISA, IF, WB.
See all TTF2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-5148
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
TTF2 (NP_003585, 2 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: EEVRCPEHGT FCFLKTGVRD GPNKGKSFYV CRADTCSFVR ATDIPVSHCL LHEDFVVELQ GLLLPQDKKE YRLFFRCIRS KAEGKRWCGS IPWQDPDSK
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 2-100

Target

Full Name
transcription termination factor, RNA polymerase II
Introduction
TTF2 is a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. TTF2 has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. TTF2 interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing.
Entrez Gene ID
8458
UniProt ID
Q9UNY4
Alternative Names
Transcription Termination Factor 2; Transcription Release Factor 2; Transcription Termination Factor, RNA Polymerase II; RNA Polymerase II Termination Factor; Zinc Finger, GRF-Type Containing 6; Lodestar Homolog; HuF2
Function
DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing.
Biological Process
Biological Process DNA repair Source:GO_Central1 Publication
Biological Process DNA-templated transcription termination Source:ProtInc1 Publication
Biological Process mRNA processing Source:UniProtKB-KW
Biological Process RNA splicing Source:UniProtKB-KW
Biological Process termination of RNA polymerase II transcription Source:ProtInc1 Publication
Cellular Location
Cytoplasm
Nucleus
Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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