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Mouse Anti-TWSG1 Recombinant Antibody (6E6) (CBMAB-A9668-LY)

The product is antibody recognizes TWSG1. The antibody 6E6 immunoassay techniques such as: WB, ELISA.
See all TWSG1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6E6
Antibody Isotype
IgG3, κ
Application
WB, ELISA

Basic Information

Immunogen
TWSG1 (NP_065699, 124 a.a. ~ 223 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG3, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
twisted gastrulation homolog 1 (Drosophila)
Entrez Gene ID
57045
UniProt ID
Q9GZX9
Alternative Names
TSG
Function
May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity).
Biological Process
Biological Process BMP signaling pathway Source:Ensembl
Biological Process camera-type eye development Source:Ensembl
Biological Process chondrocyte differentiation Source:Ensembl
Biological Process forebrain development Source:Ensembl
Biological Process hemopoiesis Source:Ensembl
Biological Process mesoderm formation Source:Ensembl
Biological Process negative regulation of BMP signaling pathway Source:Ensembl
Biological Process negative regulation of CD4-positive, alpha-beta T cell activation Source:BHF-UCL1 Publication
Biological Process negative regulation of CD4-positive, alpha-beta T cell proliferation Source:BHF-UCL1 Publication
Biological Process negative regulation of cytokine production Source:BHF-UCL1 Publication
Biological Process negative regulation of osteoblast differentiation Source:Ensembl
Biological Process ossification Source:Ensembl
Biological Process positive regulation of BMP signaling pathway Source:Ensembl
Biological Process positive regulation of pathway-restricted SMAD protein phosphorylation Source:BHF-UCL1 Publication
Biological Process regulation of BMP signaling pathway Source:GO_Central1 Publication
Biological Process salivary gland morphogenesis Source:Ensembl
Biological Process transforming growth factor beta receptor signaling pathway Source:BHF-UCL1 Publication
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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