Mouse Anti-TWSG1 Recombinant Antibody (6E6) (CBMAB-A9668-LY)

Name: Mouse Anti-TWSG1 Recombinant Antibody (6E6)
SKU: CBMAB-A9668-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

6E6

Application

WB, ELISA

Immunogen

TWSG1 (NP_065699, 124 a.a. ~ 223 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG3, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

twisted gastrulation homolog 1 (Drosophila)

Entrez Gene ID

57045

UniProt ID

Q9GZX9

Alternative Names

TSG

Function

May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity).

Biological Process

Biological Process BMP signaling pathway Source:Ensembl
Biological Process camera-type eye development Source:Ensembl
Biological Process chondrocyte differentiation Source:Ensembl
Biological Process forebrain development Source:Ensembl
Biological Process hemopoiesis Source:Ensembl
Biological Process mesoderm formation Source:Ensembl
Biological Process negative regulation of BMP signaling pathway Source:Ensembl
Biological Process negative regulation of CD4-positive, alpha-beta T cell activation Source:BHF-UCL1 Publication
Biological Process negative regulation of CD4-positive, alpha-beta T cell proliferation Source:BHF-UCL1 Publication
Biological Process negative regulation of cytokine production Source:BHF-UCL1 Publication
Biological Process negative regulation of osteoblast differentiation Source:Ensembl
Biological Process ossification Source:Ensembl
Biological Process positive regulation of BMP signaling pathway Source:Ensembl
Biological Process positive regulation of pathway-restricted SMAD protein phosphorylation Source:BHF-UCL1 Publication
Biological Process regulation of BMP signaling pathway Source:GO_Central1 Publication
Biological Process salivary gland morphogenesis Source:Ensembl
Biological Process transforming growth factor beta receptor signaling pathway Source:BHF-UCL1 Publication

Cellular Location

Secreted

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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