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Rat Anti-Twsg1 Recombinant Antibody (CBYJT-5000) (CBMAB-T4557-YJ)

Provided herein is a Rat monoclonal antibody, which binds to Twsg1 (Twisted Gastrulation BMP Signaling Modulator 1). The antibody can be used for immunoassay techniques, such as WB, IHC.
See all Twsg1 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYJT-5000
Antibody Isotype
IgG2a
Application
WB, IHC

Basic Information

Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse TSG, Cys25-Phe222, Accession # Q9EP52
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, Trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 25-222

Target

Full Name
twisted gastrulation homolog 1 (Drosophila)
Introduction
Twsg1 may be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, Twsg1 also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. Twsg1 may be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. may function in thymocyte development.
Entrez Gene ID
65960
UniProt ID
Q9EP52
Alternative Names
Tsg; Twg; AW552143; D17Ertd403e; 1810013J15Rik; 9030422N06Rik
Function
May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity).
Biological Process
Biological Process BMP signaling pathway Source:Ensembl
Biological Process camera-type eye development Source:Ensembl
Biological Process chondrocyte differentiation Source:Ensembl
Biological Process forebrain development Source:Ensembl
Biological Process hemopoiesis Source:Ensembl
Biological Process mesoderm formation Source:Ensembl
Biological Process negative regulation of BMP signaling pathway Source:Ensembl
Biological Process negative regulation of CD4-positive, alpha-beta T cell activation Source:BHF-UCL1 Publication
Biological Process negative regulation of CD4-positive, alpha-beta T cell proliferation Source:BHF-UCL1 Publication
Biological Process negative regulation of cytokine production Source:BHF-UCL1 Publication
Biological Process negative regulation of osteoblast differentiation Source:Ensembl
Biological Process ossification Source:Ensembl
Biological Process positive regulation of BMP signaling pathway Source:Ensembl
Biological Process positive regulation of pathway-restricted SMAD protein phosphorylation Source:BHF-UCL1 Publication
Biological Process regulation of BMP signaling pathway Source:GO_Central1 Publication
Biological Process salivary gland morphogenesis Source:Ensembl
Biological Process transforming growth factor beta receptor signaling pathway Source:BHF-UCL1 Publication
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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