TWSG1

Twsg1 may be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, Twsg1 also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. Twsg1 may be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. may function in thymocyte development.

Full Name

twisted gastrulation homolog 1 (Drosophila)

Function

May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity).

Biological Process

Biological Process BMP signaling pathway Source:Ensembl
Biological Process camera-type eye development Source:Ensembl
Biological Process chondrocyte differentiation Source:Ensembl
Biological Process forebrain development Source:Ensembl
Biological Process hemopoiesis Source:Ensembl
Biological Process mesoderm formation Source:Ensembl
Biological Process negative regulation of BMP signaling pathway Source:Ensembl
Biological Process negative regulation of CD4-positive, alpha-beta T cell activation Source:BHF-UCL1 Publication
Biological Process negative regulation of CD4-positive, alpha-beta T cell proliferation Source:BHF-UCL1 Publication
Biological Process negative regulation of cytokine production Source:BHF-UCL1 Publication
Biological Process negative regulation of osteoblast differentiation Source:Ensembl
Biological Process ossification Source:Ensembl
Biological Process positive regulation of BMP signaling pathway Source:Ensembl
Biological Process positive regulation of pathway-restricted SMAD protein phosphorylation Source:BHF-UCL1 Publication
Biological Process regulation of BMP signaling pathway Source:GO_Central1 Publication
Biological Process salivary gland morphogenesis Source:Ensembl
Biological Process transforming growth factor beta receptor signaling pathway Source:BHF-UCL1 Publication

Cellular Location

Secreted