Sign in or Register   Sign in or Register
  |  

Mouse Anti-NME8 Recombinant Antibody (1G5) (CBMAB-A9677-LY)

The product is antibody recognizes TXNDC3. The antibody 1G5 immunoassay techniques such as: WB, ELISA.
See all NME8 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1G5
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
TXNDC3 (NP_057700, 530 a.a. ~ 586 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
NME/NM23 Family Member 8
Introduction
TXNDC3 encodes a group II thioredoxin protein, composed of a thioredoxin domain and 3 NDP kinase domains, with testis-specific expression.[supplied by OMIM
Entrez Gene ID
51314
UniProt ID
Q8N427
Alternative Names
CILD6; NME8; SPTRX2
Function
Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds.
Biological Process
Cell differentiationIEA:UniProtKB-KW
Cellular response to reactive oxygen speciesIEA:Ensembl
Cilium assemblyManual Assertion Based On ExperimentIMP:SYSCILIA_CCNET
Flagellated sperm motilityIEA:Ensembl
SpermatogenesisIEA:UniProtKB-KW
Cellular Location
Cytoplasm
Involvement in disease
Ciliary dyskinesia, primary, 6 (CILD6):
A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-NME8 Recombinant Antibody (1G5)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare