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Mouse Anti-TXNDC5 (AA 52-63) Recombinant Antibody (2E7/7) (CBMAB-E0410-FY)

This product is mouse antibody that recognizes TXNDC5. The antibody 2E7/7 can be used for immunoassay techniques such as: ELISA, WB, IHC-P, IF, IP.
See all TXNDC5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2E7/7
Antibody Isotype
IgG2a
Application
ELISA, WB, IHC-P, IF, IP

Basic Information

Immunogen
Synthesized peptide-12 amino acids long corresponding to residues 52-63 of the EndoPDI protein
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH7.4, 50% glyercol
Preservative
0.09% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 52-63

Target

Full Name
TXNDC5
Introduction
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene.
Entrez Gene ID
81567
UniProt ID
Q8NBS9
Alternative Names
Thioredoxin Domain Containing 5; Protein Disulfide Isomerase Family A, Member 15; Endoplasmic Reticulum Resident Protein 46; Thioredoxin-Like Protein P46; ER Protein 46; ERP46; Thioredoxin Domain Containing 5 (Endoplasmic Reticulum); Endothelial Protein Disulphide Isomerase; Thioredoxin Domain-Containing Protein 5; Endoplasmic Reticulum Protein ERp46
Function
Protein disulfide isomerase of the endoplasmic reticulum lumen involved in the formation of disulfide bonds in proteins. Can reduce insulin disulfide bonds.
Biological Process
Biological Process negative regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process protein folding Source:GO_Central1 Publication
Cellular Location
Endoplasmic reticulum lumen
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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