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Rabbit Anti-TYMP Recombinant Antibody (CBYJT-5516) (CBMAB-T5132-YJ)

Provided herein is a Rabbit monoclonal antibody, which binds to TYMP (Thymidine Phosphorylase). The antibody can be used for immunoassay techniques, such as WB, IP.
See all TYMP antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYJT-5516
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Recongnizes endogenous levels of human total TP/ECGF1 protein
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
10 mM HEPES, 150 mM NaCl, pH 7.5, 100 μg/mL BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TYMP Gene(Protein Coding) Thymidine Phosphorylase
Introduction
TYMP is an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in TYMP have been associated with mitochondrial neurogastrointestinal encephalomyopathy.
Entrez Gene ID
1890
UniProt ID
P19971
Alternative Names
Thymidine Phosphorylase; Gliostatin; EC 2.4.2.4; TdRPase; ECGF1; TP; Endothelial Cell Growth Factor 1 (Platelet-Derived); Platelet-Derived Endothelial Cell Growth Factor; HPD-ECGF
Function
May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.
Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
Biological Process
Biological Process angiogenesis Source:UniProtKB-KW
Biological Process cell differentiation Source:UniProtKB-KW
Biological Process chemotaxis Source:UniProtKB-KW
Biological Process dTMP catabolic process Source:Ensembl
Biological Process mitochondrial genome maintenance Source:CAFA1 Publication
Biological Process pyrimidine nucleobase metabolic process Source:InterPro
Biological Process pyrimidine nucleoside metabolic process Source:CAFA1 Publication
Biological Process regulation of gastric motility Source:CAFA1 Publication
Biological Process regulation of myelination Source:CAFA1 Publication
Biological Process regulation of transmission of nerve impulse Source:CAFA1 Publication
Cellular Location
Cytosol
Involvement in disease
Mitochondrial DNA depletion syndrome 1, MNGIE type (MTDPS1):
A multisystem disease associated with mitochondrial dysfunction. It is clinically characterized by onset between the second and fifth decades of life, ptosis, progressive external ophthalmoplegia, gastrointestinal dysmotility (often pseudoobstruction), diffuse leukoencephalopathy, cachexia, peripheral neuropathy, and myopathy.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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