TYMP

This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012]
Full Name
TYMP Gene(Protein Coding) Thymidine Phosphorylase
Function
May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.
Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
Biological Process
Biological Process angiogenesis Source:UniProtKB-KW
Biological Process cell differentiation Source:UniProtKB-KW
Biological Process chemotaxis Source:UniProtKB-KW
Biological Process dTMP catabolic process Source:Ensembl
Biological Process mitochondrial genome maintenance Source:CAFA1 Publication
Biological Process pyrimidine nucleobase metabolic process Source:InterPro
Biological Process pyrimidine nucleoside metabolic process Source:CAFA1 Publication
Biological Process regulation of gastric motility Source:CAFA1 Publication
Biological Process regulation of myelination Source:CAFA1 Publication
Biological Process regulation of transmission of nerve impulse Source:CAFA1 Publication
Cellular Location
Cytosol
Involvement in disease
Mitochondrial DNA depletion syndrome 1, MNGIE type (MTDPS1):
A multisystem disease associated with mitochondrial dysfunction. It is clinically characterized by onset between the second and fifth decades of life, ptosis, progressive external ophthalmoplegia, gastrointestinal dysmotility (often pseudoobstruction), diffuse leukoencephalopathy, cachexia, peripheral neuropathy, and myopathy.
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Anti-TYMP antibodies

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Rabbit Anti-TYMP Recombinant Antibody (D69B12) (CBMAB-CP2830-LY)

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Target: TYMP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D69B12
Application*: WB, IP
Datasheet SDS

Recombinant Mouse Anti-TYMP Recombinant Antibody (44C) (CBMAB-XB1193-YC)

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Target: TYMP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 44C
Application*: IH, IF, IP, WB
Datasheet SDS

Mouse Anti-TYMP Recombinant Antibody (PGF 44C) (CBMAB-P3761-YC)

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Target: TYMP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: PGF 44C
Application*: WB, IH, P
Datasheet SDS

Mouse Anti-TYMP Recombinant Antibody (6A162) (CBMAB-P3760-YC)

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Target: TYMP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6A162
Application*: IH, IP, WB
Datasheet SDS

Mouse Anti-TYMP Recombinant Antibody (SPM322) (CBMAB-T5136-YJ)

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Target: TYMP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: SPM322
Application*: WB, P, IP
Datasheet SDS

Mouse Anti-TYMP Recombinant Antibody (P-GF.44C) (CBMAB-T5135-YJ)

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Target: TYMP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: P-GF.44C
Application*: C, P, WB
Datasheet SDS

Mouse Anti-TYMP Recombinant Antibody (CBYJT-5518) (CBMAB-T5134-YJ)

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Target: TYMP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBYJT-5518
Application*: IH, N
Datasheet SDS

Rabbit Anti-TYMP Recombinant Antibody (CBYJT-5517) (CBMAB-T5133-YJ)

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Target: TYMP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-5517
Application*: IP, WB
Datasheet SDS

Rabbit Anti-TYMP Recombinant Antibody (CBYJT-5516) (CBMAB-T5132-YJ)

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Target: TYMP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-5516
Application*: WB, IP
Datasheet SDS

Mouse Anti-TYMP Recombinant Antibody (CBYJT-5515) (CBMAB-T5131-YJ)

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Target: TYMP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5515
Application*: WB, IH
Datasheet SDS

Mouse Anti-TYMP Recombinant Antibody (CBYJT-5514) (CBMAB-T5130-YJ)

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Target: TYMP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5514
Application*: WB, IH
Datasheet SDS

Mouse Anti-TYMP Recombinant Antibody (CBYJT-5513) (CBMAB-T5129-YJ)

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Target: TYMP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5513
Application*: WB, IH
Datasheet SDS

Mouse Anti-TYMP Recombinant Antibody (CBYJT-5512) (CBMAB-T5128-YJ)

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Target: TYMP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5512
Application*: WB, IH
Datasheet SDS

Mouse Anti-TYMP Recombinant Antibody (CBYJT-5511) (CBMAB-T5127-YJ)

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Target: TYMP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5511
Application*: WB, IH
Datasheet SDS

Mouse Anti-TYMP Recombinant Antibody (CBYJT-5510) (CBMAB-T5126-YJ)

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Target: TYMP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5510
Application*: WB, IH
Datasheet SDS

Mouse Anti-TYMP Recombinant Antibody (CBYJT-5509) (CBMAB-T5125-YJ)

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Target: TYMP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5509
Application*: WB, IH
Datasheet SDS

Mouse Anti-TYMP Recombinant Antibody (CBYJT-5508) (CBMAB-T5124-YJ)

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Target: TYMP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5508
Application*: WB, IH
Datasheet SDS

Rabbit Anti-TYMP Recombinant Antibody (CBYJT-5507) (CBMAB-T5123-YJ)

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Target: TYMP
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-5507
Application*: IP, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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