Mouse Anti-TYMP Recombinant Antibody (P-GF.44C) (CBMAB-T5135-YJ)

Name: Mouse Anti-TYMP Recombinant Antibody (P-GF.44C)
SKU: CBMAB-T5135-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

P-GF.44C

Application

IHC-Fr, IHC-P, WB

Immunogen

Recombinant full length human thymidine phosphorylase (TP / PD-ECGF) protein

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

10 mM PBS, pH 7.4, Gelatin

Preservative

0.09% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TYMP Gene(Protein Coding) Thymidine Phosphorylase

Introduction

TYMP is an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in TYMP have been associated with mitochondrial neurogastrointestinal encephalomyopathy.

Entrez Gene ID

Human	1890
Mouse	72962
Rat	315219

UniProt ID

Human	P19971
Mouse	Q99N42
Rat	Q5FVR2

Alternative Names

Thymidine Phosphorylase; Gliostatin; EC 2.4.2.4; TdRPase; ECGF1; TP; Endothelial Cell Growth Factor 1 (Platelet-Derived); Platelet-Derived Endothelial Cell Growth Factor; HPD-ECGF

Function

May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro.
Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

Biological Process

Biological Process angiogenesis Source:UniProtKB-KW
Biological Process cell differentiation Source:UniProtKB-KW
Biological Process chemotaxis Source:UniProtKB-KW
Biological Process dTMP catabolic process Source:Ensembl
Biological Process mitochondrial genome maintenance Source:CAFA1 Publication
Biological Process pyrimidine nucleobase metabolic process Source:InterPro
Biological Process pyrimidine nucleoside metabolic process Source:CAFA1 Publication
Biological Process regulation of gastric motility Source:CAFA1 Publication
Biological Process regulation of myelination Source:CAFA1 Publication
Biological Process regulation of transmission of nerve impulse Source:CAFA1 Publication

Cellular Location

Cytosol

Involvement in disease

Mitochondrial DNA depletion syndrome 1, MNGIE type (MTDPS1):
A multisystem disease associated with mitochondrial dysfunction. It is clinically characterized by onset between the second and fifth decades of life, ptosis, progressive external ophthalmoplegia, gastrointestinal dysmotility (often pseudoobstruction), diffuse leukoencephalopathy, cachexia, peripheral neuropathy, and myopathy.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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