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Mouse Anti-UBASH3A Recombinant Antibody (CBFYU-041) (CBMAB-U0041-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYU-041
Antibody Isotype
IgG2b, Κ
Application
ELISA

Basic Information

Immunogen
UBASH3A (NP_001001895, 524 a.a. - 623 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 kD. Immunogen sequence: MDRCTASMVQ IVNTCPQDTG VILIVSHGST LDSCTRPLLG LPPRECGDFA QLVRKIPSLG MCFCEENKEE GKWELVNPPV KTLTHGANAA FNWRNWISGN.
Specificity
Human
Antibody Isotype
IgG2b, Κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 524-623

Target

Full Name
ubiquitin associated and SH3 domain containing, A
Introduction
This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface.
Entrez Gene ID
53347
UniProt ID
P57075
Alternative Names
TULA; STS-2; TULA-1; CLIP4
Function
Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.
Biological Process
Biological Process negative regulation of T cell receptor signaling pathway Source:GO_Central1 Publication
Biological Process regulation of cytokine production Source:Ensembl
Cellular Location
Cytoplasm
Nucleus
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For research use only. Not intended for any clinical use.

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