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UBASH3A

This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface.

Full Name

ubiquitin associated and SH3 domain containing, A

Function

Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.

Biological Process

Biological Process negative regulation of T cell receptor signaling pathway Source:GO_Central1 Publication
Biological Process regulation of cytokine production Source:Ensembl

Cellular Location

Cytoplasm
Nucleus

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Anti-UBASH3A antibodies

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Mouse Anti-UBASH3A Recombinant Antibody (4D2) (CBMAB-A9696-LY)

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Target: UBASH3A

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 4D2

Application*: SE, E

Mouse Anti-UBASH3A Recombinant Antibody (1G6) (CBMAB-A9695-LY)

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Target: UBASH3A

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1G6

Application*: WB, E

Rabbit Anti-UBASH3A Recombinant Antibody (CBFYU-043) (CBMAB-U0043-FY)

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Target: UBASH3A

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYU-043

Application*: E

Mouse Anti-UBASH3A Recombinant Antibody (CBFYU-042) (CBMAB-U0042-FY)

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Target: UBASH3A

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYU-042

Application*: E, IP, WB

Mouse Anti-UBASH3A Recombinant Antibody (CBFYU-041) (CBMAB-U0041-FY)

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Target: UBASH3A

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYU-041

Application*: E

Human UBASH3A ELISA Kit (V2LY-0626-LY5409)

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Target: UBASH3A

Sensitivity: 0.0051 ng/mL

Detection Range: 0.01-2 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

Human Recombinant UBASH3A protein, His Tag (V2LY-0526-LY7478)

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Target: UBASH3A

Expressed Host: E. coli

Sequence: Amino Acid: 354-623

Tag: His Tag

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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