UBASH3A

This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface.
Full Name
ubiquitin associated and SH3 domain containing, A
Function
Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.
Biological Process
Biological Process negative regulation of T cell receptor signaling pathway Source:GO_Central1 Publication
Biological Process regulation of cytokine production Source:Ensembl
Cellular Location
Cytoplasm
Nucleus
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Anti-UBASH3A antibodies

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Mouse Anti-UBASH3A Recombinant Antibody (4D2) (CBMAB-A9696-LY)

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Target: UBASH3A
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4D2
Application*: SE, E
Datasheet SDS

Mouse Anti-UBASH3A Recombinant Antibody (1G6) (CBMAB-A9695-LY)

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Target: UBASH3A
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1G6
Application*: WB, E
Datasheet SDS

Rabbit Anti-UBASH3A Recombinant Antibody (CBFYU-043) (CBMAB-U0043-FY)

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Target: UBASH3A
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYU-043
Application*: E
Datasheet SDS

Mouse Anti-UBASH3A Recombinant Antibody (CBFYU-042) (CBMAB-U0042-FY)

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Target: UBASH3A
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYU-042
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-UBASH3A Recombinant Antibody (CBFYU-041) (CBMAB-U0041-FY)

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Target: UBASH3A
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYU-041
Application*: E
Datasheet SDS

Human Recombinant UBASH3A protein, His Tag (V2LY-0526-LY7478)

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Target: UBASH3A
Expressed Host: E. coli
Sequence: Amino Acid: 354-623
Tag: His Tag
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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