Mouse Anti-UBQLN2 Recombinant Antibody (CBMAB-BR487LY)

Name: Mouse Anti-UBQLN2 Recombinant Antibody
SKU: CBMAB-BR487LY
Rating: 5 (1 reviews)

See all UBQLN2 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Application

IF: 1:1000 dilution, IHC: 1:300-1:500 dilution, WB: 0.1-0.5 μg/ml

Immunogen

Human ubiquilin 2 expressed in and purified from E. coli.

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

50% glycerol

Preservative

5mM sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Ubiquilin-2

Introduction

This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009]

Entrez Gene ID

Human	29978
Mouse	54609
Rat	317396

UniProt ID

Human	Q9UHD9
Mouse	Q9QZM0
Rat	D4AA63

Alternative Names

Ubiquilin-2;Chap1;DSK2 homolog;Protein linking IAP with cytoskeleton 2;PLIC-2;hPLIC-2;Ubiquitin-like product Chap1/Dsk2;UBQLN2;N4BP4, PLIC2;HRIHFB2157;

Biological Process

Biological Process autophagosome assembly Source:GO_Central1 Publication
Biological Process negative regulation of clathrin-dependent endocytosis Source:UniProtKB1 Publication
Biological Process negative regulation of G protein-coupled receptor internalization Source:UniProtKB1 Publication
Biological Process positive regulation of ER-associated ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Biological Process regulation of autophagosome assembly Source:UniProtKB1 Publication
Biological Process regulation of macroautophagy Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent ERAD pathway Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication

Cellular Location

Cytoplasm
Nucleus
Membrane
Cytoplasmic vesicle, autophagosome
Colocalizes with a subset of proteasomes, namely those that are cytoskeleton associated or free in the cytosol. Associated with fibers in mitotic cells.

Involvement in disease

Amyotrophic lateral sclerosis 15, with or without frontotemporal dementia (ALS15):
A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. Patients with ALS15 may develop frontotemporal dementia.

PTM

Degraded during macroautophagy.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-UBQLN2 Recombinant Antibody?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-UBQLN2 Recombinant Antibody (CBFYU-218) (CAT#: CBMAB-U0218-FY)

Mouse Anti-UBQLN2 Recombinant Antibody (3B8A10) (CAT#: CBMAB-D2365-YC)

Mouse Anti-UBQLN2 Recombinant Antibody (CBFYU-220) (CAT#: CBMAB-U0220-FY)

Mouse Anti-UBQLN2 Recombinant Antibody (CBFYU-221) (CAT#: CBMAB-U0221-FY)

Mouse Anti-UBQLN2 Recombinant Antibody (3D5E2) (CAT#: CBMAB-D2366-YC)

Rabbit Anti-UBQLN2 Recombinant Antibody (CBFYU-219) (CAT#: CBMAB-U0219-FY)

Mouse Anti-UBQLN2 Recombinant Antibody (CBFYU-217) (CAT#: CBMAB-U0217-FY)

Mouse Anti-UBQLN2 Monoclonal Antibody (1C7) (CAT#: CBMAB-0285-LY)

Mouse Anti-UBQLN2 Recombinant Antibody (CBFYU-216) (CAT#: CBMAB-U0216-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry