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UBQLN2

This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009]
Full Name
Ubiquilin-2
Biological Process
Biological Process autophagosome assembly Source:GO_Central1 Publication
Biological Process negative regulation of clathrin-dependent endocytosis Source:UniProtKB1 Publication
Biological Process negative regulation of G protein-coupled receptor internalization Source:UniProtKB1 Publication
Biological Process positive regulation of ER-associated ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Biological Process regulation of autophagosome assembly Source:UniProtKB1 Publication
Biological Process regulation of macroautophagy Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent ERAD pathway Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:GO_Central1 Publication
Cellular Location
Cytoplasm
Nucleus
Membrane
Cytoplasmic vesicle, autophagosome
Colocalizes with a subset of proteasomes, namely those that are cytoskeleton associated or free in the cytosol. Associated with fibers in mitotic cells.
Involvement in disease
Amyotrophic lateral sclerosis 15, with or without frontotemporal dementia (ALS15):
A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. Patients with ALS15 may develop frontotemporal dementia.
PTM
Degraded during macroautophagy.
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Anti-UBQLN2 antibodies

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Mouse Anti-UBQLN2 Recombinant Antibody (CBFYU-216) (CBMAB-U0216-FY)

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Target: UBQLN2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: CBFYU-216
Application*: IF, WB
Datasheet SDS

Mouse Anti-UBQLN2 Recombinant Antibody (CBMAB-BR487LY)

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Target: UBQLN2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Application*: IF, IHC, WB
Datasheet SDS

Mouse Anti-UBQLN2 Recombinant Antibody (3D5E2) (CBMAB-D2366-YC)

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Target: UBQLN2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: 3D5E2
Application*: E, F, IC, IF, P, IP, WB
Datasheet SDS

Mouse Anti-UBQLN2 Recombinant Antibody (3B8A10) (CBMAB-D2365-YC)

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Target: UBQLN2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3B8A10
Application*: E, IC, IF, WB
Datasheet SDS

Mouse Anti-UBQLN2 Recombinant Antibody (CBFYU-221) (CBMAB-U0221-FY)

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Target: UBQLN2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYU-221
Application*: WB
Datasheet SDS

Mouse Anti-UBQLN2 Recombinant Antibody (CBFYU-220) (CBMAB-U0220-FY)

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Target: UBQLN2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBFYU-220
Application*: IF, WB
Datasheet SDS

Rabbit Anti-UBQLN2 Recombinant Antibody (CBFYU-219) (CBMAB-U0219-FY)

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Target: UBQLN2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Dog
Clone: CBFYU-219
Application*: WB, IP
Datasheet SDS

Mouse Anti-UBQLN2 Recombinant Antibody (CBFYU-218) (CBMAB-U0218-FY)

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Target: UBQLN2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: CBFYU-218
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-UBQLN2 Recombinant Antibody (CBFYU-217) (CBMAB-U0217-FY)

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Target: UBQLN2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Cattle, Human, Pig
Clone: CBFYU-217
Application*: WB, P, IF
Datasheet SDS

Mouse Anti-UBQLN2 Monoclonal Antibody (1C7) (CBMAB-0285-LY)

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Target: UBQLN2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C7
Application*: IP, M, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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