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Mouse Anti-UBR4 Recombinant Antibody (2D12) (CBMAB-A7433-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2D12
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
RBAF600 (NP_065816, 94 a.a. ~ 190 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
ubiquitin protein ligase E3 component n-recognin 4
Entrez Gene ID
23352
UniProt ID
Q5T4S7
Alternative Names
FLJ41863; KIAA0462; KIAA1307; RBAF600; ZUBR1; p600
Function
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.
Biological Process
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Cellular Location
Membrane
Cytoplasm
Cytoplasm, cytoskeleton
Nucleus
Concentrates at the leading edge of membrane structures involved in actin motility.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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