Mouse Anti-UBR4 Recombinant Antibody (CBFYU-229) (CBMAB-U0229-FY)

Name: Mouse Anti-UBR4 Recombinant Antibody (CBFYU-229)
SKU: CBMAB-U0229-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBFYU-229

Application

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

ubiquitin protein ligase E3 component n-recognin 4

Introduction

This protein is a target of the human papillomavirus type 16 E7 oncoprotein.

Entrez Gene ID

23352

UniProt ID

Q5T4S7

Alternative Names

p600; ZUBR1; RBAF600

Function

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.

Biological Process

Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication

Cellular Location

Membrane
Cytoplasm
Cytoplasm, cytoskeleton
Nucleus
Concentrates at the leading edge of membrane structures involved in actin motility.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-UBR4 Recombinant Antibody (CBFYU-228) (CAT#: CBMAB-U0228-FY)

Mouse Anti-UBR4 Recombinant Antibody (2D12) (CAT#: CBMAB-A7433-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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