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Mouse Anti-UBR4 Recombinant Antibody (CBFYU-229) (CBMAB-U0229-FY)

This product is mouse antibody that recognizes UBR4. The antibody CBFYU-229 can be used for immunoassay techniques such as: WB.
See all UBR4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYU-229
Antibody Isotype
IgG2b
Application
WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ubiquitin protein ligase E3 component n-recognin 4
Introduction
This protein is a target of the human papillomavirus type 16 E7 oncoprotein.
Entrez Gene ID
23352
UniProt ID
Q5T4S7
Alternative Names
p600; ZUBR1; RBAF600
Function
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.
Biological Process
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Cellular Location
Membrane
Cytoplasm
Cytoplasm, cytoskeleton
Nucleus
Concentrates at the leading edge of membrane structures involved in actin motility.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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