UBR4

The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein.
Full Name
ubiquitin protein ligase E3 component n-recognin 4
Function
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.
Biological Process
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Cellular Location
Membrane
Cytoplasm
Cytoplasm, cytoskeleton
Nucleus
Concentrates at the leading edge of membrane structures involved in actin motility.
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Anti-UBR4 antibodies

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Mouse Anti-UBR4 Recombinant Antibody (2D12) (CBMAB-A7433-LY)

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Target: UBR4
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2D12
Application*: WB, E
Datasheet SDS

Mouse Anti-UBR4 Recombinant Antibody (CBFYU-229) (CBMAB-U0229-FY)

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Target: UBR4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYU-229
Application*: WB
Datasheet SDS

Mouse Anti-UBR4 Recombinant Antibody (CBFYU-228) (CBMAB-U0228-FY)

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Target: UBR4
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYU-228
Application*: E, IF, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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