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Mouse Anti-UCP3 Recombinant Antibody (6B8C6) (CBMAB-C4508-CN)

This product is a Mouse antibody that recognizes UCP3. The antibody 6B8C6 can be used for immunoassay techniques such as: ELISA, WB, IF.
See all UCP3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
6B8C6
Antibody Isotype
IgG2a
Application
ELISA, WB, IF

Basic Information

Immunogen
Recombinant fragment of human UCP3 (AA: 1-113 and 217-312) expressed in E. Coli
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS
Preservative
0.05% Sodium azide

Target

Full Name
Uncoupling Protein 3
Introduction
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008]
Entrez Gene ID
7352
UniProt ID
P55916
Alternative Names
Uncoupling Protein 3; Uncoupling Protein 3 (Mitochondrial, Proton Carrier); Solute Carrier Family 25 Member 9; SLC25A9; Mitochondrial Uncoupling Protein 3; UCP 3;
Function
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance.
Biological Process
Biological Process adaptive thermogenesis Source:GO_Central1 Publication
Biological Process aging Source:Ensembl
Biological Process cellular response to hormone stimulus Source:Ensembl
Biological Process fatty acid metabolic process Source:Ensembl
Biological Process lipid metabolic process Source:ProtInc1 Publication
Biological Process mitochondrial transmembrane transport Source:GO_Central1 Publication
Biological Process mitochondrial transport Source:InterPro
Biological Process proton transmembrane transport Source:ProtInc1 Publication
Biological Process respiratory gaseous exchange by respiratory system Source:ProtInc1 Publication
Biological Process response to activity Source:Ensembl
Biological Process response to cold Source:GO_Central1 Publication
Biological Process response to glucocorticoid Source:Ensembl
Biological Process response to hypoxia Source:Ensembl
Biological Process response to insulin Source:Ensembl
Biological Process response to nutrient Source:Ensembl
Biological Process response to superoxide Source:Ensembl
Cellular Location
Mitochondrion inner membrane
Involvement in disease
Obesity (OBESITY):
A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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