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Mouse Anti-UNC5A Recombinant Antibody (Dettwy-1) (CBMAB-C4661-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
Dettwy-1
Antibody Isotype
IgG1
Application
ELISA, FC

Basic Information

Immunogen
Extracellular domain of human UNC5A (aa 26-306) fused to the Fc portion of human IgG1
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide

Target

Full Name
Unc-5 Netrin Receptor A
Introduction
UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM, Apr 2004]
Entrez Gene ID
90249
UniProt ID
Q6ZN44
Alternative Names
Unc-5 Netrin Receptor A; Unc5 (C.Elegans Homolog) A; Protein Unc-5 Homolog 1; Protein Unc-5 Homolog A; UNC5H1; Unc-5 Homolog A (C. Elegans);
Function
Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
Biological Process
Biological Process anterior/posterior axon guidance Source:GO_Central1 Publication
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process axon guidance Source:GO_Central1 Publication
Biological Process netrin-activated signaling pathway Source:UniProtKB
Biological Process neuron projection development Source:UniProtKB
Cellular Location
Cell membrane
Membrane raft
Cell projection, neuron projection
The interaction with PRKCABP regulates its surface expression and leads to its removal from the surface of neurons and growth cones.
Topology
Extracellular: 26-306
Helical: 307-327
Cytoplasmic: 328-842
PTM
Phosphorylated on cytoplasmic tyrosine residues (By similarity).
Phosphorylated by PKC in vitro (By similarity).
Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.
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For research use only. Not intended for any clinical use.

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