UNC5A

UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM, Apr 2004]

Full Name

Unc-5 Netrin Receptor A

Function

Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.

Biological Process

Biological Process anterior/posterior axon guidance Source:GO_Central1 Publication
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process axon guidance Source:GO_Central1 Publication
Biological Process netrin-activated signaling pathway Source:UniProtKB
Biological Process neuron projection development Source:UniProtKB

Cellular Location

Cell membrane
Membrane raft
Cell projection, neuron projection
The interaction with PRKCABP regulates its surface expression and leads to its removal from the surface of neurons and growth cones.

Topology

Extracellular: 26-306
Helical: 307-327
Cytoplasmic: 328-842

PTM

Phosphorylated on cytoplasmic tyrosine residues (By similarity).
Phosphorylated by PKC in vitro (By similarity).
Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.