Mouse Anti-UNC5B Recombinant Antibody (187305) (CBMAB-C4662-CN)

Name: Mouse Anti-UNC5B Recombinant Antibody (187305)
SKU: CBMAB-C4662-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

187305

Application

Immunogen

Mouse myeloma cell line NS0-derived recombinant rat UNC5H2, Gly27-Asp373, Accession # O08722

Specificity

Rat

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, Trehalose. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS

More Infomation

Target

Full Name

Unc-5 Netrin Receptor B

Introduction

This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

Entrez Gene ID

60630

UniProt ID

O08722

Alternative Names

Unc-5 Netrin Receptor B; P53-Regulated Receptor For Death And Life Protein 1; Protein Unc-5 Homolog 2; Protein Unc-5 Homolog B; P53RDL1; UNC5H2; Transmembrane Receptor Unc5H2;

Function

Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity).
Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity).
It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906).
Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity).

Biological Process

Biological Process angiogenesis Source:UniProtKB-KW
Biological Process anterior/posterior axon guidance Source:GO_Central1 Publication
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process axon guidance Source:GO_Central1 Publication
Biological Process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source:UniProtKB1 Publication
Biological Process negative regulation of neuron apoptotic process Source:UniProtKB1 Publication
Biological Process positive regulation of phosphatidylinositol 3-kinase signaling Source:UniProtKB1 Publication

Cellular Location

Cell membrane
Membrane raft
Associated with lipid rafts.

Topology

Extracellular: 27-377
Helical: 378-398
Cytoplasmic: 399-945

PTM

Phosphorylated on cytoplasmic tyrosine residues.
Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.
Palmitoylation is required for pro-apoptotic activity, but not for location at lipid rafts.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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