Sign in or Register   Sign in or Register
  |  

Mouse Anti-UNC5B Recombinant Antibody (187305) (CBMAB-C4662-CN)

This product is a Mouse antibody that recognizes UNC5B. The antibody 187305 can be used for immunoassay techniques such as: WB.
See all UNC5B antibodies
Published Data
Fig.1 Unc5B protein expression level in the periinfarct cortex did not change significantly at various time points after dMCAO.
...View More
Fig.2 Unc5B (green) colocalized with the neuronal marker b-tubulin III (red) in the peri-infarct cortex at 1 day after dMCAO.
...View More

Summary

Host Animal
Mouse
Specificity
Rat
Clone
187305
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant rat UNC5H2, Gly27-Asp373, Accession # O08722
Specificity
Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS

Target

Full Name
Unc-5 Netrin Receptor B
Introduction
This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
Entrez Gene ID
60630
UniProt ID
O08722
Alternative Names
Unc-5 Netrin Receptor B; P53-Regulated Receptor For Death And Life Protein 1; Protein Unc-5 Homolog 2; Protein Unc-5 Homolog B; P53RDL1; UNC5H2; Transmembrane Receptor Unc5H2;
Function
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity).
Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity).
It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906).
Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity).
Biological Process
Biological Process angiogenesis Source:UniProtKB-KW
Biological Process anterior/posterior axon guidance Source:GO_Central1 Publication
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process axon guidance Source:GO_Central1 Publication
Biological Process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source:UniProtKB1 Publication
Biological Process negative regulation of neuron apoptotic process Source:UniProtKB1 Publication
Biological Process positive regulation of phosphatidylinositol 3-kinase signaling Source:UniProtKB1 Publication
Cellular Location
Cell membrane
Membrane raft
Associated with lipid rafts.
Topology
Extracellular: 27-377
Helical: 378-398
Cytoplasmic: 399-945
PTM
Phosphorylated on cytoplasmic tyrosine residues.
Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.
Palmitoylation is required for pro-apoptotic activity, but not for location at lipid rafts.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-UNC5B Recombinant Antibody (187305)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare