Human UNC5B ELISA Kit (V2LY-0626-LY4095)
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Basic Information
- Pre-coated ELISA Plate: 12 wells * 8 detachable strips
- Standard solution: 0.5ml x1
- Standard diluent: 3ml x1
- Streptavidin-HRP: 6ml x1
- Stop solution: 6ml x1
- Substrate solution A: 6ml x1
- Substrate solution B: 6ml x1
- Wash buffer concentrate (25x): 20ml x1
- Biotinylated antibody: 1ml x1
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity).
It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906).
Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity).
Biological Process anterior/posterior axon guidance Source:GO_Central1 Publication
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process axon guidance Source:GO_Central1 Publication
Biological Process negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source:UniProtKB1 Publication
Biological Process negative regulation of neuron apoptotic process Source:UniProtKB1 Publication
Biological Process positive regulation of phosphatidylinositol 3-kinase signaling Source:UniProtKB1 Publication
Membrane raft
Associated with lipid rafts.
Helical: 378-398
Cytoplasmic: 399-945
Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.
Palmitoylation is required for pro-apoptotic activity, but not for location at lipid rafts.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Alternative Versions
Human Recombinant UNC5B protein, ECD, hFc Tag (CAT#: V2LY-0526-LY7548)
Rat Recombinant UNC5B protein, hFc Tag (CAT#: V2LY-0526-LY9631)
Related Products
Mouse Anti-UNC5B Recombinant Antibody (Guido-1) (CAT#: CBMAB-0932CQ)
Mouse Anti-UNC5B Recombinant Antibody (CBWJN-1702) (CAT#: CBMAB-N4355-WJ)
Rabbit Anti-UNC5B Recombinant Antibody (D9M7Z) (CAT#: CBMAB-C4664-CN)
Human Recombinant UNC5B protein, ECD, His Tag (CAT#: V2LY-0526-LY7549)
Human Recombinant UNC5B protein, ECD, hFc Tag (CAT#: V2LY-0526-LY7548)
Rat Recombinant UNC5B protein, hFc Tag (CAT#: V2LY-0526-LY9631)
Mouse Anti-UNC5B Recombinant Antibody (187305) (CAT#: CBMAB-C4662-CN)
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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