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Mouse Anti-UNC5D Recombinant Antibody (4G3) (CBMAB-C4672-CN)

This product is a Mouse antibody that recognizes UNC5D. The antibody 4G3 can be used for immunoassay techniques such as: ELISA, WB.
See all UNC5D antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4G3
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant protein corresponding to aa 31-131 from human UNC5D (NP_543148) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
unc-5 homolog D (C. elegans)
Introduction
Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). May play a role in apoptosis in response to DNA damage (PubMed:24691657). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:24519068). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity).
Entrez Gene ID
137970
UniProt ID
Q6UXZ4
Alternative Names
Unc-5 Netrin Receptor D; Protein Unc-5 Homolog 4; Protein Unc-5 Homolog D; Netrin Receptor UNC5D; Unc5h4; Unc-5 Homolog D (C. Elegans);
Function
Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity).
Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity).
May play a role in apoptosis in response to DNA damage (PubMed:24691657).
It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:24519068).
Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity).
Biological Process
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process axon guidance Source:GO_Central1 Publication
Biological Process cell-cell adhesion via plasma-membrane adhesion molecules Source:UniProtKB1 Publication
Biological Process pyramidal neuron differentiation Source:Ensembl
Biological Process regulation of neuron migration Source:Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 33-379
Helical: 380-400
Cytoplasmic: 401-953
PTM
Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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