Human UNC5D ELISA Kit (V2LY-0626-LY4094)

Name: Human UNC5D ELISA Kit
SKU: V2LY-0626-LY4094
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

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Basic Information

Sensitivity

0.046 ng/mL

Detection Range

0.1-40 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

105.9 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

unc-5 homolog D (C. elegans)

Function

Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity).
Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity).
May play a role in apoptosis in response to DNA damage (PubMed:24691657).
It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:24519068).
Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity).

Biological Process

Biological Process apoptotic process Source:UniProtKB-KW
Biological Process axon guidance Source:GO_Central1 Publication
Biological Process cell-cell adhesion via plasma-membrane adhesion molecules Source:UniProtKB1 Publication
Biological Process pyramidal neuron differentiation Source:Ensembl
Biological Process regulation of neuron migration Source:Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 33-379
Helical: 380-400
Cytoplasmic: 401-953

PTM

Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-UNC5D Recombinant Antibody (4G3) (CAT#: CBMAB-C4672-CN)

Mouse Anti-UNC5D Recombinant Antibody (CBCNC-795) (CAT#: CBMAB-C4673-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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