UNC5D

Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). May play a role in apoptosis in response to DNA damage (PubMed:24691657). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:24519068). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity).

Full Name

unc-5 homolog D (C. elegans)

Function

Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity).
Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity).
May play a role in apoptosis in response to DNA damage (PubMed:24691657).
It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:24519068).
Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity).

Biological Process

Biological Process apoptotic process Source:UniProtKB-KW
Biological Process axon guidance Source:GO_Central1 Publication
Biological Process cell-cell adhesion via plasma-membrane adhesion molecules Source:UniProtKB1 Publication
Biological Process pyramidal neuron differentiation Source:Ensembl
Biological Process regulation of neuron migration Source:Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 33-379
Helical: 380-400
Cytoplasmic: 401-953

PTM

Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.