UNC5D

Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). May play a role in apoptosis in response to DNA damage (PubMed:24691657). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:24519068). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity).

unc-5 homolog D (C. elegans)

Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity).
Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity).
May play a role in apoptosis in response to DNA damage (PubMed:24691657).
It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:24519068).
Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity).

Biological Process apoptotic process Source:UniProtKB-KW
Biological Process axon guidance Source:GO_Central1 Publication
Biological Process cell-cell adhesion via plasma-membrane adhesion molecules Source:UniProtKB1 Publication
Biological Process pyramidal neuron differentiation Source:Ensembl
Biological Process regulation of neuron migration Source:Ensembl

Cell membrane

Extracellular: 33-379
Helical: 380-400
Cytoplasmic: 401-953

Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis.