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Rabbit Anti-USP1 Recombinant Antibody (CBXU-154) (CBMAB-U0223-CQ)

This product is a rabbit antibody that recognizes USP1. The antibody CBXU-154 can be used for immunoassay techniques such as: WB, IP.
See all USP1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Monkey, Rat
Clone
CBXU-154
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Mouse, Monkey, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ubiquitin Specific Peptidase 1
Introduction
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins.
Entrez Gene ID
Human7398
Mouse230484
Rat313387
Monkey695157
UniProt ID
HumanO94782
MouseQ8BJQ2
RatQ569C3
MonkeyG7MHB3
Alternative Names
UBP
Function
Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335).
Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995, PubMed:20147293).
Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029).
Biological Process
Biological Process DNA repair Source:UniProtKB-KW
Biological Process monoubiquitinated protein deubiquitination Source:UniProtKB1 Publication
Biological Process positive regulation of error-prone translesion synthesis Source:Reactome
Biological Process protein deubiquitination Source:UniProtKB1 Publication
Biological Process regulation of DNA repair Source:UniProtKB1 Publication
Biological Process response to UV Source:UniProtKB1 Publication
Biological Process skeletal system development Source:Ensembl
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro
Cellular Location
Nucleus
PTM
Autocatalytic cleavage of USP1 following UV irradiation inactivates it, leading to an increase in ubiquitinated PCNA, recruitment of POLH and translesion synthesis.
Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment
Ubiquitinated by the CRL2(KLHDC2) complex following autocatalytic cleavage, leading to its degradation: the CRL2(KLHDC2) complex recognizes the diglycine (Gly-Gly) at the C-terminus.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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